- Senior Laboratory Research Scientist in Alessandro Costa's Molecular Machines group
Closing date and time:
- 30 April 2021, 23:59
- Alessandro Costa
- This is a full-time and permanent position on Crick terms and conditions of employment.
We are looking for an experienced researcher passionate about molecular mechanisms. The candidate will be involved in collaborative research projects, will help with training junior lab members in protein biochemistry and structural biology, and help with the day-to-day running of the lab.
The Molecular Machines laboratory focuses on understanding the mechanism of chromosome replication using biochemical reconstitution and cryo-electron microscopy. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/alessandro-costa and https://www.alecostalab.net/
These include but are not limited to:
- Designing and conducting scientific experiments independently or in collaboration with other group members.
- Cloning, expressing and purifying multi-component protein assemblies.
- Conducting chromosome replication reactions to be monitored biochemically, or using light and cryo-electron microscopy.
- Training junior lab members in protein biochemistry and structural biology techniques.
- Helping with the day-to-day running of the lab, including organising lab space and ordering consumables.
Key experience and competencies
- PhD in Biochemistry, Structural Biology (and related fields) or in the final stages of PhD submission.
- Knowledge and experience in molecular cloning, protein expression and purification.
- Experience in experimental design.
- Ability to work independently and in collaboration with other group members.
Different profiles will be a suitable fit in the lab. These include individuals with experience in
- conducting enzymatic assays (e.g. nucleic acid polymerasation, kinase and ATPase).
- nucleosome reconstitution and chromatin biology.
- atomic model building.
- working with Unix and coding in Python.
- Single-molecule fluorescence microscopy.