Project summary
An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science, in the laboratory of Samra Turajlic (Cancer Dynamics, https://www.crick.ac.uk/research/labs/samra-turajlic). We are seeking a highly collaborative and self-motivated post-doctoral bioinformatician to work within our comprehensive tumour evolution programme, collaborating with a network of groups across The Francis Crick Institute, UCL Cancer Institute, the Institute of Cancer Research, as well as internationally, including NIH (US) and pharma. The position will involve analysis of data from large-scale tumour evolutionary trials such as the TRACERx and PEACE studies as well as interventional clinical trials, such as ADAPTeR and A-PREDICT and the 100KG Genomics England datasets. Our studies have underpinned a wide number of successful contributions to the field of tumour evolution and achieved an excellent track record of high impact output. This project sits at the interface of basic and translational research and will be utilising a rich multi-omic datasets (bulk and single cell) generated from large-scale trials run locally and internationally as well as pre-clinical models. Our focus are renal cell carcinoma and melanoma, however some of the bioinformatic projects are also conducted in the pan-cancer setting, while others are focused on clinical adoption of biomarkers. The role is ideally suited for a creative individual with a strong interest in cancer genomics, cancer evolution, evolutionary biology, and software / pipeline development in a leading academic setting.
The successful applicant will have a proven track record in cancer bioinformatics, with previous experience of NGS data analysis, and be fluent in at least one of the following programming languages: Python or R, and is expected to have strong skills in genomics and/or cancer biology and/or evolution. Prior experience with data analysis based on integrating large datasets is particularly desired. The position will be based within a multi-disciplinary team of cancer evolutionary biologists, wet-lab scientists and translational research clinicians concerned with both basic evolutionary principles and application of evolutionary rules in the clinic. We collaborate closely with colleagues specialising in machine learning and mathematical modelling. Further, the lab also has a strong focus on understanding anti-tumour immune response and tackling this through both wet lab and dry lab work. The applicant will have the opportunity to develop collaborations nationally and internationally, and there will be an opportunity to engage with our industry and academic partners. The candidate will work closely with other computational scientists at Francis Crick Institute and have ample opportunities to develop their skills. A comprehensive computational infrastructure is available, with access to multiple HPC clusters.
Project scope
The proposed project leverages four programmes: TRACERx Renal (http://tracerx.co.uk/studies/renal/), NIH (https://grantome.com/grant/NIH/U01-CA247439-01) HOLST-F (https://www.annalsofoncology.org/article/S0923-7534(19)60107-9/fulltext), and PEACE (https://clinicaltrials.gov/ct2/show/NCT03004755, renal cancer and melanoma). The research is conducted in close collaboration with the Royal Marsden, Guy's and St Thomas' and Royal Free NHS Foundation Trusts and several international collaborators, including at the National Institute of Health, US.
Dr Samra Turajlic is a Clinician Scientist with clinical practice in renal cell cancer and melanoma and the programme reflects emerging clinical questions tackled through a combination of cutting-edge methods. The overall aim of the lab is to yield fundamental biological insights, decipher the impact of selection and influence of the tumour microenvironment, immune system and cancer therapy on clonal evolution; and to apply this knowledge to improve patient outcomes. The successful applicant will be employed by the Francis Crick Institute and based within Dr Turajlic’s group, funded by Cancer Research UK, NIH, Melanoma Research Alliance, the Rosetrees Trust, and the NIHR Biomedical Research Centre, amongst others. The Francis Crick Institute offers an impressive computational infrastructure and additional resources are available through the CRUK City of London Centre and eMedLab, and there are ample opportunities for personal development .
Information about the work of the laboratory can be found through the links below:
https://www.crick.ac.uk/research/labs/samra-turajlic
https://scholar.google.co.uk/citations?view_op=new_articles&hl=en&imq=samra+turajlic#
https://orcid.org/0000-0001-8846-136X
For further details please do not hesitate to contact samra.turajlic@crick.ac.uk
Key Responsibilities
The primary duty of the post-holder will be to conduct bioinformatics discovery analysis, into the evolutionary drivers of metastasis and tumour progression, immune-escape and treatment resistance. The project will make use of what is thought to be one of the world’s largest datasets of genomic/transcriptomic data from several cancer evolution trials. Sequencing data is complimented by a wealth of supporting data-types, including histological, imaging data, clinical and radiomics data.
To work within the bioinformatics team of the Turajlic lab, and collaborating groups at Francis Crick Institute and beyond, including academic and industry partners.
To conduct analyses of genomic, transcriptomic and imaging data, using established pipelines.
To develop new informatic methods as dictated by project needs
To employ novel informatics methods to apply to cell-free and single cell data including in-situ transcriptomics
To liaise and coordinate between the project collaborators which include clinicians, cancer biologists, machine learning experts and mathematical modellers.
To record all analyses in an accurate, timely and clearly presented manner, and use this to prepare data summaries and reports as and when required.
To understand tumour evolution and the relevant literature (cancer biology, cancer genomics) sufficiently to propose novel ideas.
To drive the project forward through making biological insights, integrating them with pre-clinical models and clinical studies and generating new hypotheses
To attend, and report research results at regular group meetings.
To contribute to the dissemination of scientific results by means of writing papers for publication, and presenting orally and in poster form at national and international meetings.
To contribute to the broader research programme of Turajlic lab intellectually and practically
To support junior colleagues as necessary
Any other duties appropriate to the scope and grade of the post. The job description may be subject to review and amendment in consultation with the post holder as job duties change/develop
Key Experience and Competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following essential criteria:
Post-doctoral qualification (PhD) in Bio-informatics
Fluent in at least one of the following programming languages: C++, Python or R
Excellent understanding of mathematics and statistics, including experience of Baysian statistitcs
Evidence of independent and original contribution to research
Previous experience of multidisciplinary working
Ability to manage projects to timelines, analyse, present and write up data in a timely manner
Excellent presentation skills- including at international conferences
Excellent general computational skills
Ability to represent the PI at meetings and conferences
Excellent inter-personal skills and commitment to team-work
Ability to work with minimal supervision using own initiative to organise and prioritise own work
Ability to define and solve research questions
Pro-active in innovation and problem solving
Experience in the field of evolutionary biology/cancer evolution is desired
Experience with single cell sequencing and imaging analyses is desirable
Experience with machine learning is desirable
