Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Vacancies Find links to current vacancies, and information about recruitment to various types of role.
Outwitting Cancer25 Sep -15 Jul Meet the Crick's trailblazing scientists who are helping to turn the tide on one of the world’s biggest killers.
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Research A Z researchers Ben Clarke POSTDOC - SECONDMENT Patani lab Human Stem Cells and Neurodegeneration Laboratory Year published2022 (2)2021 (4)2020 (2) Facet Year publishedResearch topicsCell Biology (8)Chemical Biology & High Throughput (1)Computational & Systems Biology (2)Gene Expression (2)Genetics & Genomics (2)Genome Integrity & Repair (1)Neurosciences (8)Stem Cells (8)Tumour Biology (2) Facet Research topicsPublication typeJournal article (8)Primary research (4)Review (4) Facet Publication typeJournalAntioxidants (1)Brain (3)Genome Research (1)Glia (1)Nucleic Acids Research (1)Progress in Neurobiology (1) Facet JournalCrick Pre-CrickCrick publications (8) Facet Crick Pre-Crick Displaying 1 - 8 of 8Last updated : 01 April 2023 03:49 Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 19 January 2022 Crick labsRickie PataniFull details Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3)Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 19 January 2022 Crick labsRickie PataniFull details
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3)Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details
The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details
Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details
