Ian Rosewell

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Authors (27)

Elizabeth R Murray
Shinelle Menezes
Jack C Henry
Josie L Williams
Lorena Alba-Castellón
Priththivika Baskaran
[...]
Nuria Gavara
Oliver Pearce
Pedro Cutillas
John F Marshall
Angus JM Cameron

Cell Reports

Published 25 January 2022

Crick labs/ facilities

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USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

Authors (32)

Josue Ruiz
Adan Pinto-Fernandez
Andrew P Turnbull
Linxiang Lan
Thomas M Charlton
Hannah Claire Scott
[...]
David Komander
Sylvie Urbé
Michael J Clague
Benedikt M Kessler
Axel Behrens

eLife

Published 12 October 2021

Crick labs/ facilities

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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

Authors (17)

Evangelos Giampazolias
Oliver Schulz
Jonathan Lim
Neil Rogers
Probir Chakravarty
Naren Srinivasan
[...]
Stefano Sammicheli
Natalia Moncaut
Sunita Varsani-Brown
Ian Rosewell
Caetano Reis e Sousa

Cell

Published 22 July 2021

Crick labs/ facilities

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The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo

Authors (8)

BMC developmental biology

Published 22 March 2021

Crick labs/ facilities

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RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Authors (17)

Daniël A Lionarons
David Hancock
Sareena Rana
Philip East
Christopher Moore
Miguel Murillo
[...]
Ian Rosewell
Ralph Fritsch
Richard Neubig
Miriam Molina Arcas
Julian Downward

Cancer Cell

Published 8 July 2019

Crick labs/ facilities

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Duct- and acinar-derived pancreatic ductal adenocarcinomas show distinct tumor progression and marker expression

Authors (10)

Rute Machado De Morais Ferreira
Rocio Sancho
Hendrik Messal
Emma Nye
Bradley Spencer-Dene
Richard Stone
Gordon Stamp
Ian Rosewell
Alberto Quaglia
Axel Behrens

Cell Reports

Published 24 October 2017

Crick labs/ facilities

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Knockout of the PKN family of Rho effector kinases reveals a non-redundant role for PKN2 in developmental mesoderm expansion

Authors (18)

Ivan Quétier
Jacqui Marshall
Bradley Spencer-Dene
Sylvie Lachmann
Adele Casamassima
Claudio Franco
[...]
Ian Rosewell
Pedro Cutillas
Holger Gerhardt
Peter Parker
Angus JM Cameron

Cell Reports

Published 26 January 2016

Crick labs/ facilities

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Runx2 contributes to the regenerative potential of the mammary epithelium

Authors (13)

Nicola Ferrari
Alessandra I Riggio
Susan Mason
Laura McDonald
Ayala King
Theresa Higgins
[...]
Matthew J Smalley
Owen J Sansom
Joanna Morris
Ewan R Cameron
Karen Blyth

Scientific Reports

Published 22 October 2015

Crick labs/ facilities

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Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses

Authors (10)

Delphine Goubau
Annemarthe G van der Veen
Probir Chakravarty
Rongtuan Lin
Neil Rogers
Jan Rehwinkel
Safia Deddouche
Ian Rosewell
John Hiscott
Caetano Reis e Sousa

European Journal of Immunology

Published 1 December 2015

Crick labs/ facilities

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Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Authors (16)

Sophie E Acton
Aaron J Farrugia
Jillian L Astarita
Diego Mourão-Sá
Rob Jenkins
Emma Nye
[...]
Luis F Moita
Gordon Stamp
Shannon J Turley
Erik Sahai
Caetano Reis e Sousa

Nature

Published 23 October 2014

Crick labs/ facilities

Full details

Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors

Authors (8)

Marco Terenzio
Matthew Golding
Matt Russell
Krzysztof B Wicher
Ian Rosewell
Bradley Spencer-Dene
David Ish-Horowicz
Giampietro Schiavo

EMBO Journal

Published 17 July 2014

Crick labs/ facilities

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Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

Authors (14)

Denise Stenzel
Claudio A Franco
Soline Estrach
Amel Mettouchi
Dominique Sauvaget
Ian Rosewell
[...]
Sergey Rodin
Karl Tryggvason
Lucy Collinson
Lydia Sorokin
Holger Gerhardt

EMBO Reports

Published 1 November 2011

Crick labs/ facilities

Full details

Coronavirus (COVID-19) response

Vacancies

Outwitting Cancer

Coronavirus (COVID-19) research

About us

Ian Rosewell

HEAD OF GEMS

Biological Research Facility: Genetic Modification Service

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Duct- and acinar-derived pancreatic ductal adenocarcinomas show distinct tumor progression and marker expression

Knockout of the PKN family of Rho effector kinases reveals a non-redundant role for PKN2 in developmental mesoderm expansion

Runx2 contributes to the regenerative potential of the mammary epithelium

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

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