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Breadcrumb Research A Z researchers Rachel Rosenthal VISITING SCIENTIST Swanton lab Cancer Evolution and Genome Instability Laboratory Year published2021 (5)2020 (5)2019 (3)2018 (4)2017 (4)2016 (3) Facet Year publishedResearch topicsChemical Biology & High Throughput (24)Computational & Systems Biology (24)Developmental Biology (2)Gene Expression (4)Genetics & Genomics (24)Genome Integrity & Repair (24)Human Biology & Physiology (24)Model Organisms (2)Signalling & Oncogenes (24)Tumour Biology (24) Facet Research topicsPublication typeCommentary (1)Journal article (24)Primary research (22)Review (1) Facet Publication typeJournalAnnals of Oncology (4)British Journal of Cancer (1)Cancer Cell (1)Cancer Discovery (1)Cell (2)Clinical cancer research (1)Genome Biology (1)Lancet Oncology (1)Nature (5)Nature Biotechnology (1)Nature Cancer (1)Nature Medicine (3)New England Journal of Medicine (1)Science (1) Facet JournalCrick Pre-CrickCrick publications (24) Facet Crick Pre-Crick Displaying 1 - 20 of 24Last updated : 28 March 2023 03:33 Julie Nielsen 6 Nielsen JulieEmail address @email PHD STUDENT On Off Off On Treisman lab Signalling and Transcription Laboratory Search engines may index Using DNA sequencing data to quantify T cell fraction and therapy response Authors (14) Robert Bentham Kevin LitchfieldTom WatkinsEmilia LimRachel Rosenthal Carlos Martínez-Ruiz[...] David A Moore Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Published 23 September 2021 Crick labs/ facilitiesCharles SwantonScientific computingFull details Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion Authors (28) Fabio Conforti Laura Pala Eleonora Pagan Vincenzo Bagnardi Tommaso De Pas Paola Queirolo[...] Alberto Mantovani Richard D Gelber Giuseppe Viale Aron Goldhirsch Giuseppe Giaccone Clinical cancer research Published 1 August 2021 Crick labsCharles SwantonFull details Understanding the impact of immune-mediated selection on lung cancer evolution Authors (3)Rachel RosenthalCharles Swanton Nicholas McGranahan British Journal of Cancer Published 11 May 2021 Crick labsCharles SwantonFull details Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition Authors (28)Kevin Litchfield James L Reading Clare Puttick Krupa Thakkar Chris Abbosh Robert Bentham[...] Matthew D HellmannSamra Turajlic Sergio A Quezada Nicholas McGranahanCharles Swanton Cell Published 4 February 2021 Crick labsPeter Van LooSamra TurajlicCharles SwantonFull details Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details Immune surveillance in clinical regression of preinvasive squamous cell lung cancer Authors (38) Adam Pennycuick Vitor H Teixeira Khalid AbdulJabbar Shan E Ahmed Raza Tom Lund Ayse U Akarca[...] Teresa Marafioti Yinyin Yuan Sergio A Quezada Nicholas McGranahan Sam M Janes Cancer Discovery Published 1 October 2020 Crick labsCharles SwantonFull details Geospatial immune variability illuminates differential evolution of lung adenocarcinoma Authors (24) Khalid AbdulJabbar Shan E Ahmed RazaRachel RosenthalMariam Jamal-HanjaniSelvaraju Veeriah Ayse Akarca[...] Nicholas McGranahan John Le Quesne TRACERx ConsortiumCharles Swanton Yinyin Yuan Nature Medicine Published 27 May 2020 Crick labsPeter Van LooCharles SwantonFull details The T cell differentiation landscape is shaped by tumour mutations in lung cancer Authors (51) Ehsan Ghorani James L Reading Jake Y Henry Marc Robert de MassyRachel Rosenthal Virginia Turati[...] Karl S Peggs Nicholas McGranahan Benny ChainCharles Swanton Sergio A Quezada Nature Cancer Published 1 May 2020 Crick labsPeter Van LooCharles SwantonFull details Unintended on-target chromosomal instability following CRISPR/Cas9 single gene targeting Authors (5)Aska (Joanna) PrzewrockaAndrew RowanRachel Rosenthal N KanuCharles Swanton Annals of Oncology Published 1 September 2020 Crick labs/ facilitiesCharles SwantonHigh Throughput ScreeningAdvanced SequencingFull details A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details Neoantigen-directed immune escape in lung cancer evolution Authors (29)Rachel RosenthalElizabeth Larose Cadieux Roberto SalgadoMaise Al Bakir David A MooreCrispin Hiley[...]Peter Van Loo Stephan Beck Nicholas McGranahanCharles Swanton The TRACERx Consortium Nature Published 20 March 2019 Crick labs/ facilitiesPeter Van LooCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Fc effector function contributes to the activity of human anti-CTLA-4 antibodies Authors (35) Frederick Arce Vargas Andrew JS FurnessKevin Litchfield Kroopa JoshiRachel Rosenthal Ehsan Ghorani[...] James LarkinSamra TurajlicCharles Swanton Karl S Peggs Sergio A Quezada Cancer Cell Published 9 April 2018 Crick labsSamra TurajlicCharles SwantonFull details Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution Authors (9)Subramanian VenkatesanRachel Rosenthal N Kanu N McGranahan J Bartek SA Quezada J Hare RS HarrisCharles Swanton Annals of Oncology Published 1 March 2018 Crick labsCharles SwantonFull details Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma Authors (8) E GhoraniRachel Rosenthal N McGranahan JL Reading M Lynch KS PeggsCharles Swanton SA Quezada Annals of Oncology Published 1 January 2018 Crick labsCharles SwantonFull details Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters Authors (34) M Linch G GohCrispin Hiley Y Shanmugabavan N McGranahanAndrew Rowan[...] SA Quezada T Marafioti M Gerlinger HU AhmedCharles Swanton Annals of Oncology Published 1 October 2017 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis Authors (20)Samra TurajlicKevin LitchfieldHang XuRachel Rosenthal Nicholas McGranahan James L Reading[...] Laurent Sansregret Martin Gore James Larkin Sergio A QuezadaCharles Swanton Lancet Oncology Published 1 August 2017 Crick labsSamra TurajlicCharles SwantonFull details Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Julie Nielsen 6 Nielsen JulieEmail address @email PHD STUDENT On Off Off On Treisman lab Signalling and Transcription Laboratory Search engines may index
Using DNA sequencing data to quantify T cell fraction and therapy response Authors (14) Robert Bentham Kevin LitchfieldTom WatkinsEmilia LimRachel Rosenthal Carlos Martínez-Ruiz[...] David A Moore Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Published 23 September 2021 Crick labs/ facilitiesCharles SwantonScientific computingFull details
Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion Authors (28) Fabio Conforti Laura Pala Eleonora Pagan Vincenzo Bagnardi Tommaso De Pas Paola Queirolo[...] Alberto Mantovani Richard D Gelber Giuseppe Viale Aron Goldhirsch Giuseppe Giaccone Clinical cancer research Published 1 August 2021 Crick labsCharles SwantonFull details
Understanding the impact of immune-mediated selection on lung cancer evolution Authors (3)Rachel RosenthalCharles Swanton Nicholas McGranahan British Journal of Cancer Published 11 May 2021 Crick labsCharles SwantonFull details
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition Authors (28)Kevin Litchfield James L Reading Clare Puttick Krupa Thakkar Chris Abbosh Robert Bentham[...] Matthew D HellmannSamra Turajlic Sergio A Quezada Nicholas McGranahanCharles Swanton Cell Published 4 February 2021 Crick labsPeter Van LooSamra TurajlicCharles SwantonFull details
Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details
Immune surveillance in clinical regression of preinvasive squamous cell lung cancer Authors (38) Adam Pennycuick Vitor H Teixeira Khalid AbdulJabbar Shan E Ahmed Raza Tom Lund Ayse U Akarca[...] Teresa Marafioti Yinyin Yuan Sergio A Quezada Nicholas McGranahan Sam M Janes Cancer Discovery Published 1 October 2020 Crick labsCharles SwantonFull details
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma Authors (24) Khalid AbdulJabbar Shan E Ahmed RazaRachel RosenthalMariam Jamal-HanjaniSelvaraju Veeriah Ayse Akarca[...] Nicholas McGranahan John Le Quesne TRACERx ConsortiumCharles Swanton Yinyin Yuan Nature Medicine Published 27 May 2020 Crick labsPeter Van LooCharles SwantonFull details
The T cell differentiation landscape is shaped by tumour mutations in lung cancer Authors (51) Ehsan Ghorani James L Reading Jake Y Henry Marc Robert de MassyRachel Rosenthal Virginia Turati[...] Karl S Peggs Nicholas McGranahan Benny ChainCharles Swanton Sergio A Quezada Nature Cancer Published 1 May 2020 Crick labsPeter Van LooCharles SwantonFull details
Unintended on-target chromosomal instability following CRISPR/Cas9 single gene targeting Authors (5)Aska (Joanna) PrzewrockaAndrew RowanRachel Rosenthal N KanuCharles Swanton Annals of Oncology Published 1 September 2020 Crick labs/ facilitiesCharles SwantonHigh Throughput ScreeningAdvanced SequencingFull details
A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details
Neoantigen-directed immune escape in lung cancer evolution Authors (29)Rachel RosenthalElizabeth Larose Cadieux Roberto SalgadoMaise Al Bakir David A MooreCrispin Hiley[...]Peter Van Loo Stephan Beck Nicholas McGranahanCharles Swanton The TRACERx Consortium Nature Published 20 March 2019 Crick labs/ facilitiesPeter Van LooCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies Authors (35) Frederick Arce Vargas Andrew JS FurnessKevin Litchfield Kroopa JoshiRachel Rosenthal Ehsan Ghorani[...] James LarkinSamra TurajlicCharles Swanton Karl S Peggs Sergio A Quezada Cancer Cell Published 9 April 2018 Crick labsSamra TurajlicCharles SwantonFull details
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution Authors (9)Subramanian VenkatesanRachel Rosenthal N Kanu N McGranahan J Bartek SA Quezada J Hare RS HarrisCharles Swanton Annals of Oncology Published 1 March 2018 Crick labsCharles SwantonFull details
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma Authors (8) E GhoraniRachel Rosenthal N McGranahan JL Reading M Lynch KS PeggsCharles Swanton SA Quezada Annals of Oncology Published 1 January 2018 Crick labsCharles SwantonFull details
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters Authors (34) M Linch G GohCrispin Hiley Y Shanmugabavan N McGranahanAndrew Rowan[...] SA Quezada T Marafioti M Gerlinger HU AhmedCharles Swanton Annals of Oncology Published 1 October 2017 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis Authors (20)Samra TurajlicKevin LitchfieldHang XuRachel Rosenthal Nicholas McGranahan James L Reading[...] Laurent Sansregret Martin Gore James Larkin Sergio A QuezadaCharles Swanton Lancet Oncology Published 1 August 2017 Crick labsSamra TurajlicCharles SwantonFull details
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
