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Breadcrumb Research A Z researchers Stefania Crotta SENIOR LABORATORY RESEARCH SCIENTIST Wack lab Immunoregulation Laboratory Email Address: Email Year published2021 (7)2020 (2)2019 (1)2018 (1)2016 (2)2015 (2)2014 (2)2013 (1)2010 (1) Facet Year publishedResearch topicsCell Biology (1)Chemical Biology & High Throughput (3)Computational & Systems Biology (4)Developmental Biology (2)Gene Expression (1)Genetics & Genomics (3)Genome Integrity & Repair (3)Human Biology & Physiology (14)Imaging (1)Immunology (14)Infectious Disease (14)Model Organisms (14)Signalling & Oncogenes (2)Stem Cells (3)Tumour Biology (5) Facet Research topicsPublication typeJournal article (19)Primary research (18) Facet Publication typeJournalCell (3)Cell Reports (1)EMBO Molecular Medicine (1)EMBO Reports (1)Immunity (1)iScience (1)Journal of Experimental Medicine (1)Journal of hepatology (1)Journal of Immunology (1)Nature Communications (2)Nature Immunology (1)PLOS ONE (1)PLOS Pathogens (1)Science (1)Science Immunology (2) Facet JournalCrick Pre-CrickCrick publications (18)Pre-Crick publications (1) Facet Crick Pre-Crick Displaying 1 - 19 of 19Last updated : 01 April 2023 03:51 Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaJohn McCauleyDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium Authors (12) Jacob Thyrsted Jacob Storgaard Julia Blay-Cadanet Alexander Heinz Anne Laugaard ThielkeStefania Crotta[...] David OlagnierAndreas Wack Karsten Hiller Anne Louise Hansen Christian Kanstrup Holm iScience Published 19 November 2021 Crick labsAndreas WackFull details A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza Authors (6)Julie RappeKatja FinsterbuschStefania Crotta Matthias Mack Simon L PriestnallAndreas Wack Journal of Experimental Medicine Published 1 November 2021 Crick labs/ facilitiesAndreas WackExperimental HistopathologyFlow CytometryBiological Research FacilityFull details Clare Weeden 7 Weeden Clare PROJECT RESEARCH SCIENTIST Off Off On Swanton lab Cancer Evolution and Genome Instability Laboratory Search engines may index The interferon landscape along the respiratory tract impacts the severity of COVID-19 Authors (28) Benedetta Sposito Achille Broggi Laura PandolfiStefania Crotta Nicola Clementi Roberto Ferrarese[...] Antonio E Pontiroli Federica MeloniAndreas Wack Nicasio Mancini Ivan Zanoni Cell Published 16 September 2021 Crick labsAndreas WackFull details Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Authors (15) Daniel Schnepf Pedro Hernandez Tanel MahlakõivStefania Crotta Meagan E Sullender Stefan T Peterson[...] Celso A Reis Andreas DiefenbachAndreas Wack Megan T Baldridge Peter Staeheli PLOS ONE Published 12 August 2021 Crick labsAndreas WackFull details Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details Type I and III interferons disrupt lung epithelial repair during recovery from viral infection Authors (8)Jack MajorStefania Crotta Miriam Llorian Teresa M McCabe Hans Henrik Gad Simon L Priestnall Rune HartmannAndreas Wack Science Published 7 August 2020 Crick labs/ facilitiesAndreas WackExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection Authors (9) Helena AegerterJustina KulikauskaiteStefania Crotta Harshil PatelGavin Kelly Edith M Hessel Matthias Mack Soren BeinkeAndreas Wack Nature Immunology Published 1 February 2020 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection Authors (9)Konrad BradleyKatja Finsterbusch Daniel SchnepfStefania Crotta Miriam Llorian Sophia Davidson Serge Y Fuchs Peter StaeheliAndreas Wack Cell Reports Published 2 July 2019 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity Authors (10) Amina MetidjiSara OmenettiStefania CrottaYing LiEmma Nye Ellie RossVivian LiMurali Maradana Chris SchieringBrigitta Stockinger Immunity Published 21 August 2018 Crick labs/ facilitiesAndreas WackGitta StockingerVivian LiExperimental HistopathologyFlow CytometryCell ServicesBiological Research FacilityFull details The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis Authors (9) Matteo VillaStefania Crotta Kevin S Dingwell Elizabeth MA Hirst Manolis Gialitakis Helena AhlforsJim SmithBrigitta StockingerAndreas Wack Nature Communications Published 26 August 2016 Crick labs/ facilitiesAndreas WackGitta StockingerJim SmithElectron MicroscopyLight MicroscopyBiological Research FacilityAdvanced SequencingFull details IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment Authors (8) Sophia Davidson Teresa M McCabeStefania Crotta Hans Henrik Gad Edith M Hessel Soren Beinke Rune HartmannAndreas Wack EMBO Molecular Medicine Published 1 September 2016 Crick labs/ facilitiesAndreas WackFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection Authors (6) Gregory T Ellis Sophia DavidsonStefania Crotta Nora BranzkVenizelos PapayannopoulosAndreas Wack EMBO Reports Published 1 September 2015 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityFull details A serpin shapes the extracellular environment to prevent influenza A virus maturation Authors (15) Meike Dittmann Hans-Heinrich Hoffmann Margaret A Scull Rachel H Gilmore Kierstin L Bell Michael Ciancanelli[...] Jing W Xiao Jean-Laurent CasanovaAndreas Wack Paul D Bieniasz Charles M Rice Cell Published 12 February 2015 Crick labsAndreas WackFull details The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development Authors (8)Stefania Crotta Annita Gkioka Victoria Male João H Duarte Sophia Davidson Ilaria Nisoli Hugh JM BradyAndreas Wack Journal of Immunology Published 17 February 2014 Crick labsAndreas WackFull details Pathogenic potential of interferon αβ in acute influenza infection Authors (4) Sophia DavidsonStefania Crotta Teresa M McCabeAndreas Wack Nature Communications Published 1 January 2014 Crick labsAndreas WackFull details Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia Authors (8)Stefania Crotta Sophia Davidson Tanel Mahlakoiv Christophe J Desmet Matthew R Buckwalter Matthew L Albert Peter StaeheliAndreas Wack PLOS Pathogens Published 1 November 2013 Crick labsAndreas WackFull details Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection Authors (5)Stefania Crotta M Brazzoli D Piccioli NM ValianteAndreas Wack Journal of hepatology Published 1 February 2010 Crick labsAndreas WackFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaJohn McCauleyDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium Authors (12) Jacob Thyrsted Jacob Storgaard Julia Blay-Cadanet Alexander Heinz Anne Laugaard ThielkeStefania Crotta[...] David OlagnierAndreas Wack Karsten Hiller Anne Louise Hansen Christian Kanstrup Holm iScience Published 19 November 2021 Crick labsAndreas WackFull details
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza Authors (6)Julie RappeKatja FinsterbuschStefania Crotta Matthias Mack Simon L PriestnallAndreas Wack Journal of Experimental Medicine Published 1 November 2021 Crick labs/ facilitiesAndreas WackExperimental HistopathologyFlow CytometryBiological Research FacilityFull details
Clare Weeden 7 Weeden Clare PROJECT RESEARCH SCIENTIST Off Off On Swanton lab Cancer Evolution and Genome Instability Laboratory Search engines may index
The interferon landscape along the respiratory tract impacts the severity of COVID-19 Authors (28) Benedetta Sposito Achille Broggi Laura PandolfiStefania Crotta Nicola Clementi Roberto Ferrarese[...] Antonio E Pontiroli Federica MeloniAndreas Wack Nicasio Mancini Ivan Zanoni Cell Published 16 September 2021 Crick labsAndreas WackFull details
Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Authors (15) Daniel Schnepf Pedro Hernandez Tanel MahlakõivStefania Crotta Meagan E Sullender Stefan T Peterson[...] Celso A Reis Andreas DiefenbachAndreas Wack Megan T Baldridge Peter Staeheli PLOS ONE Published 12 August 2021 Crick labsAndreas WackFull details
Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection Authors (8)Jack MajorStefania Crotta Miriam Llorian Teresa M McCabe Hans Henrik Gad Simon L Priestnall Rune HartmannAndreas Wack Science Published 7 August 2020 Crick labs/ facilitiesAndreas WackExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection Authors (9) Helena AegerterJustina KulikauskaiteStefania Crotta Harshil PatelGavin Kelly Edith M Hessel Matthias Mack Soren BeinkeAndreas Wack Nature Immunology Published 1 February 2020 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection Authors (9)Konrad BradleyKatja Finsterbusch Daniel SchnepfStefania Crotta Miriam Llorian Sophia Davidson Serge Y Fuchs Peter StaeheliAndreas Wack Cell Reports Published 2 July 2019 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity Authors (10) Amina MetidjiSara OmenettiStefania CrottaYing LiEmma Nye Ellie RossVivian LiMurali Maradana Chris SchieringBrigitta Stockinger Immunity Published 21 August 2018 Crick labs/ facilitiesAndreas WackGitta StockingerVivian LiExperimental HistopathologyFlow CytometryCell ServicesBiological Research FacilityFull details
The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis Authors (9) Matteo VillaStefania Crotta Kevin S Dingwell Elizabeth MA Hirst Manolis Gialitakis Helena AhlforsJim SmithBrigitta StockingerAndreas Wack Nature Communications Published 26 August 2016 Crick labs/ facilitiesAndreas WackGitta StockingerJim SmithElectron MicroscopyLight MicroscopyBiological Research FacilityAdvanced SequencingFull details
IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment Authors (8) Sophia Davidson Teresa M McCabeStefania Crotta Hans Henrik Gad Edith M Hessel Soren Beinke Rune HartmannAndreas Wack EMBO Molecular Medicine Published 1 September 2016 Crick labs/ facilitiesAndreas WackFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection Authors (6) Gregory T Ellis Sophia DavidsonStefania Crotta Nora BranzkVenizelos PapayannopoulosAndreas Wack EMBO Reports Published 1 September 2015 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
A serpin shapes the extracellular environment to prevent influenza A virus maturation Authors (15) Meike Dittmann Hans-Heinrich Hoffmann Margaret A Scull Rachel H Gilmore Kierstin L Bell Michael Ciancanelli[...] Jing W Xiao Jean-Laurent CasanovaAndreas Wack Paul D Bieniasz Charles M Rice Cell Published 12 February 2015 Crick labsAndreas WackFull details
The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development Authors (8)Stefania Crotta Annita Gkioka Victoria Male João H Duarte Sophia Davidson Ilaria Nisoli Hugh JM BradyAndreas Wack Journal of Immunology Published 17 February 2014 Crick labsAndreas WackFull details
Pathogenic potential of interferon αβ in acute influenza infection Authors (4) Sophia DavidsonStefania Crotta Teresa M McCabeAndreas Wack Nature Communications Published 1 January 2014 Crick labsAndreas WackFull details
Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia Authors (8)Stefania Crotta Sophia Davidson Tanel Mahlakoiv Christophe J Desmet Matthew R Buckwalter Matthew L Albert Peter StaeheliAndreas Wack PLOS Pathogens Published 1 November 2013 Crick labsAndreas WackFull details
Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection Authors (5)Stefania Crotta M Brazzoli D Piccioli NM ValianteAndreas Wack Journal of hepatology Published 1 February 2010 Crick labsAndreas WackFull details
