Steven Hooper

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

Authors (11)

Manuela Zangrossi
Patrizia Romani
Probir Chakravarty
Colin Ratcliffe
Steven Hooper
Martina Dori
Mattia Forcato
Silvio Bicciato
Sirio Dupont
Erik Sahai
Marco Montagner

Cancers

Published 3 March 2021

Crick labs/ facilities

Full details

A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Authors (7)

Manuela Zangrossi
Probir Chakravarty
Patrizia Romani
Sirio Dupont
Steven Hooper
Erik Sahai
Marco Montagner

Cancers (Basel)

Published 28 February 2021

Crick labs/ facilities

Full details

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Authors (9)

Cell Reports

Published 16 February 2021

Crick labs/ facilities

Full details

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Authors (10)

Esther Arwert
Emma Milford
Toni Rullan Iriarte
Stefanie Derzsi
Steven Hooper
Takuya Kato
David Mansfield
Alan Melcher
Kevin J Harrington
Erik Sahai

Nature Cell Biology

Published 1 July 2020

Crick labs/ facilities

Full details

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Authors (12)

Marco Montagner
Rahul Bhome
Steven Hooper
Probir Chakravarty
Xiao Qin
Jahangir Sufi
[...]
Colin Ratcliffe
Yutaka Naito
Arianna Pocaterra
Christopher J Tape
Erik Sahai

Nature Cell Biology

Published 1 March 2020

Crick labs/ facilities

Full details

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukaemia cells from oxidative stress

Authors (23)

Richard Burt
Aditi Dey
Sarah Aref
Melanie Aguiar
Ayse Akarca
Katharine Bailey
[...]
Constandina Pospori
Ignazio Puccio
Krisztina Zuborne-Alapi
Erik Sahai
Adele K Fielding

Blood

Published 24 October 2019

Crick labs

Erik Sahai

Full details

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Authors (8)

Hugh Sparks
Hiroshi Kondo
Steven Hooper
Ian Munro
Gordon Kennedy
Christopher Dunsby
Paul French
Erik Sahai

Nature Communications

Published 9 July 2018

Crick labs/ facilities

Full details

Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export

Authors (8)

Cell systems

Published 27 June 2018

Crick labs/ facilities

Full details

Cdc42EP3/BORG2 and septin network enables mechano-transduction and the emergence of cancer-associated fibroblasts

Authors (9)

Fernando Calvo
Romana Ranftl
Steven Hooper
Aaron J Farrugia
Emad Moeendarbary
Andreas Bruckbauer
Facundo Batista
Guillaume Charras
Erik Sahai

Cell Reports

Published 29 December 2015

Crick labs

Erik Sahai

Full details

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

Authors (9)

Eishu Hirata
Maria Romina Girotti
Amaya Viros
Steven Hooper
Bradley Spencer-Dene
Michiyuki Matsuda
James Larkin
Richard Marais
Erik Sahai

Cancer Cell

Published 13 April 2015

Crick labs/ facilities

Full details

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

Authors (11)

Amine Sadok
Afshan McCarthy
John Caldwell
Ian Collins
Michelle D Garrett
Maggie Yeo
Steven Hooper
Erik Sahai
Sandra Kuemper
Faraz K Mardakheh
Christopher J Marshall

Cancer Research

Published 1 June 2015

Crick labs

Erik Sahai

Full details

STRIPAK components determine mode of cancer cell migration and metastasis

Authors (9)

Chris D Madsen
Steven Hooper
Melda Tozluoglu
Andreas Bruckbauer
Georgina Fletcher
Janine T Erler
Paul Bates
Barry Thompson
Erik Sahai

Nature Cell Biology

Published 1 January 2015

Crick labs

Full details

Coronavirus (COVID-19) response

Vacancies

Outwitting Cancer

Coronavirus (COVID-19) research

About us

Steven Hooper

PRINCIPAL LABORATORY RESEARCH SCIENTIST

Sahai lab

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukaemia cells from oxidative stress

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export

Cdc42EP3/BORG2 and septin network enables mechano-transduction and the emergence of cancer-associated fibroblasts

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

STRIPAK components determine mode of cancer cell migration and metastasis

The Francis Crick Institute is a unique partnership between