Valerie Borel

PRINCIPAL LABORATORY RESEARCH SCIENTIST

DNA damage in mouse embryonic stem cells.

Boulton lab

DSB Repair Metabolism Laboratory

Phone Number:
+44 (0)20 3796 1199

Displaying 1 - 9 of 9

Last updated : 06 June 2023 02:05

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Authors (27)

Graeme Hewitt
Valerie Borel
Sandra Segura-Bayona
Tohru Takaki
Philip Ruis
Roberto Bellelli
[...]
Ivan Ahel
Dragana Ahel
J Ross Chapman
Sebastian Deindl
Simon Boulton

Molecular Cell

Published 18 February 2021

Crick labs/ facilities

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TRF2-independent chromosome end protection during pluripotency

Authors (13)

Philip Ruis
David Van Ly
Valerie Borel
Georgia R Kafer
Afshan Mccarthy
Steven Howell
[...]
James Briscoe
Kathy Niakan
Paulina Marzec
Anthony J Cesare
Simon Boulton

Nature

Published 7 January 2021

Crick labs/ facilities

Full details

Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

Authors (6)

Roberto Bellelli
Jillian Youds
Valerie Borel
Jennifer Svendsen
Visnja Pavicic-Kaltenbrunner
Simon Boulton

Cell Reports

Published 26 May 2020

Crick labs/ facilities

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CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Authors (12)

Grzegorz Sarek
Panagiotis Kotsantis
Philip Ruis
David Van Ly
Pol Margalef
Valerie Borel
[...]
Helen R Flynn
Bram Snijders
Dipanjan Chowdhury
Anthony J Cesare
Simon Boulton

Nature

Published 13 November 2019

Crick labs/ facilities

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DNA polymerase epsilon deficiency causes IMAGe syndrome with variable immunodeficiency

Authors (47)

Clare V Logan
Jennie E Murray
David A Parry
Andrea Robertson
Roberto Bellelli
Žygimantė Tarnauskaitė
[...]
Michael B Bober
Robert K Semple
Simon Boulton
Jonathan J Rios
Andrew P Jackson

American Journal of Human Genetics

Published 29 November 2018

Crick labs

Simon Boulton

Full details

Polε instability drives replication stress, abnormal development, and tumorigenesis

Authors (14)

Roberto Bellelli
Valerie Borel
Clare Logan
Jennifer Svendsen
Danielle Cox
Emma Nye
[...]
Helen R Flynn
Bram Snijders
François Lassailly
Andrew Jackson
Simon Boulton

Molecular Cell

Published 17 May 2018

Crick labs/ facilities

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Stabilization of reversed replication forks by telomerase drives telomere catastrophe

Authors (6)

Cell

Published 25 January 2018

Crick labs/ facilities

Full details

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway

Authors (5)

Kenichiro Matsuzaki
Valerie Borel
Carrie A Adelman
Detlev Schindler
Simon Boulton

Genes & Development

Published 15 December 2015

Crick labs/ facilities

Full details

BOD1L is required to suppress deleterious resection of stressed replication forks

Authors (14)

Martin R Higgs
John J Reynolds
Alicja Winczura
Andrew N Blackford
Valerie Borel
Edward S Miller
[...]
Nicholas J Davies
Tatjana Stankovic
Simon Boulton
Wojciech Niedzwiedz
Grant S Stewart

Molecular Cell

Published 6 August 2015

Crick labs

Simon Boulton

Full details

Coronavirus (COVID-19) response

Vacancies

Outwitting Cancer

Coronavirus (COVID-19) research

About us

Valerie Borel

PRINCIPAL LABORATORY RESEARCH SCIENTIST

Boulton lab

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

TRF2-independent chromosome end protection during pluripotency

Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

DNA polymerase epsilon deficiency causes IMAGe syndrome with variable immunodeficiency

Polε instability drives replication stress, abnormal development, and tumorigenesis

Stabilization of reversed replication forks by telomerase drives telomere catastrophe

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway

BOD1L is required to suppress deleterious resection of stressed replication forks

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