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Breadcrumb Charles Swanton Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Illustration of chromosomes from a cancer cell showing large-scale alterations. Toggle to view hero caption PublicationsYear published2022 (3)2021 (42)2020 (42)2019 (25)2018 (27)2017 (36)2016 (23)2015 (28)2014 (28)2013 (23)2012 (18)2011 (11)2010 (12) Facet Year publishedResearch topicsChemical Biology & High Throughput (215)Computational & Systems Biology (215)Genetics & Genomics (215)Genome Integrity & Repair (215)Human Biology & Physiology (215)Signalling & Oncogenes (215)Tumour Biology (215)Cell Biology (33)Model Organisms (30)Stem Cells (23)Cell Cycle & Chromosomes (22)Structural Biology & Biophysics (22)Infectious Disease (21)Immunology (20)Metabolism (19)Neurosciences (19)Biochemistry & Proteomics (18)Developmental Biology (14)Gene Expression (13)Imaging (12)Synthetic Biology (3)Microfabrication & Bioengineering (1) Facet Research topicsPublication typeJournal article (318)Primary research (167)Review (97)Commentary (27)Letter (10)Editorial (9)Method (4)Book review (1)Obituary (1)Policy letter (1) Facet Publication typeJournalAnnals of Oncology (38)Cancer Discovery (15)Nature (13)Nature Communications (12)Cell (11)Cancer Cell (9)Lancet Oncology (9)Cancer Research (8)Nature Medicine (8)Nature Reviews Clinical Oncology (8)Journal of Pathology (7)The Lancet (7)Genome Biology (6)Nature Cancer (6)New England Journal of Medicine (6)British Journal of Cancer (5)EPMA Journal (5)Science (5)Journal of Clinical Oncology (4)Lancet (4)Nature Genetics (4)Oncogene (4)Clinical cancer research (3)Cold Spring Harbor Perspectives in Medicine (3)European Urology (3)npj Breast Cancer (3)PLOS Medicine (3)PLOS ONE (3)Science Translational Medicine (3)ASCO Educational Book (2)Autophagy (2)Breast Cancer Research (2)Breast Cancer Research and Treatment (2)Cell Reports (2)European Journal of Cancer (2)Frontiers in Oncology (2)Gastroenterology (2)Genome Medicine (2)Journal of Cell Science (2)Journal of Experimental Medicine (2)Journal of Thoracic Oncology (2)Methods in Molecular Biology (2)Nature Biotechnology (2)Nature Ecology and Evolution (2)Nature Reviews Urology (2)Oncologist (2)Oncotarget (2)The Lancet Oncology (2)American Journal of Pathology (1)Annals of the New York Academy of Sciences (1)Annals of Translational Medicine (1)Annual Review of Genetics (1)Biochemical Pharmacology (1)Biochemical Society Transactions (1)Biochimica et Biophysica Acta (1)BJU international (1)BMC Bioinformatics (1)BMC Medical Genomics (1)BMC Medicine (1)BMJ (1)Breast (1)CA: a cancer journal for clinicians (1)Cancer Epidemiology, Biomarkers & Prevention (1)Cancer Immunology, Immunotherapy (1)Cancer Letters (1)Cancer Prevention Research (1)Cell Cycle (1)Clinical Chemistry (1)Clinical Medicine (1)Clinical Oncology (1)Current Biology (1)Current Cancer Drug Targets (1)Current Opinion in Genetics & Development (1)Current Opinion in Pharmacology (1)Current Opinion in Systems Biology (1)Current Opinion in Urology (1)Disease Models & Mechanisms (1)Drugs (1)eLife (1)EMBO Molecular Medicine (1)EMBO Reports (1)Epilepsy and Behavior (1)ESMO Open (1)Evolutionary Applications (1)Expert Review of Anticancer Therapy (1)G3 (1)Immunity (1)Immunological Reviews (1)International Journal of Cancer (1)Investigational New Drugs (1)Journal of Cellular Biochemistry (1)Journal of Clinical Investigation (1)Journal of hepatology (1)Journal of the Royal Society of Medicine (1)Molecular & Cellular Oncology (1)Molecular Oncology (1)Mutagenesis (1)Nature Reviews Cancer (1)Nature Reviews Disease Primers (1)Nature Reviews Drug Discovery (1)Nature Reviews Genetics (1)Neuro-Oncology (1)Nucleic Acids Research (1)Open Biology (1)Orvosi Hetilap (1)PLOS Biology (1)Scientific Reports (1)Seminars in Cancer Biology (1)Supportive Care in Cancer (1)The EMBO Journal (1)Trends in Cancer (1)Trends in Cell Biology (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 318Last updated : 06 June 2023 03:01 Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 25 January 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 20 January 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 January 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 29 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Atezolizumab treatment of tumors with high tumor mutational burden from MyPathway, a multicenter, open-label, phase 2a multiple basket study Authors (14) Claire F Friedman John D Hainsworth Razelle Kurzrock David R Spigel Howard A Burris Christopher J Sweeney[...] Jessica Grindheim David S Shames Katja Schulze Arisha PatelCharles Swanton Cancer Discovery Published 7 December 2021 Crick labsCharles SwantonFull details The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group Authors (75) K El Bairi HR Haynes E Blackley S Fineberg J Shear S Turner[...] MV Dieci S Michiels S Demaria S Loi The International Immuno-Oncology Biomarker Working Group npj Breast Cancer Published 1 December 2021 Crick labsCharles SwantonFull details A state-of the-art review of stratified medicine in cancer: towards a future precision medicine strategy in cancer Authors (4) G Middleton H Robbins F AndreCharles Swanton Annals of Oncology Published 1 February 2022 Crick labsCharles SwantonFull details Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma Authors (207)Lewis Au Emine Hatipoglu Marc Robert de MassyKevin Litchfield Gordon BeattieAndrew Rowan[...] Jonathon Olsburgh Alexander Polson Sarah Rudman Mary Varia Hema Verma Cancer Cell Published 8 November 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonGeorge KassiotisBioinformatics and BiostatisticsAdvanced SequencingExperimental HistopathologyFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors Authors (2) Christopher AbboshCharles Swanton PLOS Medicine Published 12 October 2021 Crick labsCharles SwantonFull details Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe Van MaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details Joanna Evans 4 Evans JoannaEmail address @email Senior Laboratory Research Scientist (SCIENCE) On Off Off On Johnson lab Systems Chemical Biology of Infection and Resistance Laboratory Search engines may index 9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy Authors (32) Guangchun Han Guoliang Yang Dapeng Hao Yang Lu Kyaw Thein Benjamin S Simpson[...]Charles Swanton Kevin Litchfield Jordi Rodon Ahnert Jianjun Gao Linghua Wang Nature Communications Published 23 September 2021 Crick labsCharles SwantonFull details Julie Nielsen 6 Nielsen JulieEmail address @email PHD STUDENT On Off Off On Treisman lab Signalling and Transcription Laboratory Search engines may index Using DNA sequencing data to quantify T cell fraction and therapy response Authors (14) Robert Bentham Kevin LitchfieldTom WatkinsEmilia LimRachel Rosenthal Carlos Martínez-Ruiz[...] David A Moore Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Published 23 September 2021 Crick labs/ facilitiesCharles SwantonScientific computingFull details Cancer evolution: Darwin and beyond Authors (3)Roberto Vendramin Kevin LitchfieldCharles Swanton The EMBO Journal Published 15 September 2021 Crick labsCharles SwantonFull details Capturing cancer evolution using genetically engineered mouse models (GEMMs) Authors (3)William HillDeborah CaswellCharles Swanton Trends in Cell Biology Published 1 December 2021 Crick labsCharles SwantonFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 25 January 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 20 January 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 January 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 29 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Atezolizumab treatment of tumors with high tumor mutational burden from MyPathway, a multicenter, open-label, phase 2a multiple basket study Authors (14) Claire F Friedman John D Hainsworth Razelle Kurzrock David R Spigel Howard A Burris Christopher J Sweeney[...] Jessica Grindheim David S Shames Katja Schulze Arisha PatelCharles Swanton Cancer Discovery Published 7 December 2021 Crick labsCharles SwantonFull details
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group Authors (75) K El Bairi HR Haynes E Blackley S Fineberg J Shear S Turner[...] MV Dieci S Michiels S Demaria S Loi The International Immuno-Oncology Biomarker Working Group npj Breast Cancer Published 1 December 2021 Crick labsCharles SwantonFull details
A state-of the-art review of stratified medicine in cancer: towards a future precision medicine strategy in cancer Authors (4) G Middleton H Robbins F AndreCharles Swanton Annals of Oncology Published 1 February 2022 Crick labsCharles SwantonFull details
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma Authors (207)Lewis Au Emine Hatipoglu Marc Robert de MassyKevin Litchfield Gordon BeattieAndrew Rowan[...] Jonathon Olsburgh Alexander Polson Sarah Rudman Mary Varia Hema Verma Cancer Cell Published 8 November 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonGeorge KassiotisBioinformatics and BiostatisticsAdvanced SequencingExperimental HistopathologyFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors Authors (2) Christopher AbboshCharles Swanton PLOS Medicine Published 12 October 2021 Crick labsCharles SwantonFull details
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry Authors (18)Febe Van MaldegemKarishma ValandMegan Cole Harshil PatelMihaela AngelovaSareena Rana[...]Philip HobsonDina LeviMiriam Molina ArcasCharles SwantonJulian Downward Nature Communications Published 8 October 2021 Crick labs/ facilitiesCharles SwantonJulian DownwardFlow CytometryBioinformatics and BiostatisticsScientific computingLight MicroscopyExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Joanna Evans 4 Evans JoannaEmail address @email Senior Laboratory Research Scientist (SCIENCE) On Off Off On Johnson lab Systems Chemical Biology of Infection and Resistance Laboratory Search engines may index
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy Authors (32) Guangchun Han Guoliang Yang Dapeng Hao Yang Lu Kyaw Thein Benjamin S Simpson[...]Charles Swanton Kevin Litchfield Jordi Rodon Ahnert Jianjun Gao Linghua Wang Nature Communications Published 23 September 2021 Crick labsCharles SwantonFull details
Julie Nielsen 6 Nielsen JulieEmail address @email PHD STUDENT On Off Off On Treisman lab Signalling and Transcription Laboratory Search engines may index
Using DNA sequencing data to quantify T cell fraction and therapy response Authors (14) Robert Bentham Kevin LitchfieldTom WatkinsEmilia LimRachel Rosenthal Carlos Martínez-Ruiz[...] David A Moore Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Published 23 September 2021 Crick labs/ facilitiesCharles SwantonScientific computingFull details
Cancer evolution: Darwin and beyond Authors (3)Roberto Vendramin Kevin LitchfieldCharles Swanton The EMBO Journal Published 15 September 2021 Crick labsCharles SwantonFull details
Capturing cancer evolution using genetically engineered mouse models (GEMMs) Authors (3)William HillDeborah CaswellCharles Swanton Trends in Cell Biology Published 1 December 2021 Crick labsCharles SwantonFull details