Publications

Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Authors (35)

Xiao Fu
Yue Zhao
Jose I Lopez
Andrew Rowan
Lewis Au
Annika Fendler
[...]
Erik Sahai
Kevin Litchfield
Samra Turajlic
TRACERx Renal Consortium
Paul Bates

Nature Ecology and Evolution

Published 1 January 2022

Crick labs/ facilities

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Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Authors (18)

Science Immunology

Published 5 November 2021

Crick labs/ facilities

Full details

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling

Authors (11)

Anna Dowbaj
Rob Jenkins
Daniel Williamson
John M Heddleston
Alessandro Ciccarelli
Todd Fallesen
Klaus M Hahn
Reuben D O'Dea
John R King
Marco Montagner
Erik Sahai

Journal of Cell Science

Published 9 July 2021

Crick labs/ facilities

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The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis

Authors (14)

Cedric Tehranian
Laura Fankhauser
Patrick N Harter
Colin Ratcliffe
Pia S Zeiner
Julia M Messmer
[...]
Michael W Ronellenfitsch
Erik Sahai
Wolfgang Wick
Matthia A Karreman
Frank Winkler

Neuro-Oncology

Published 1 February 2022

Crick labs

Erik Sahai

Full details

Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion

Authors (5)

Daniel E Williamson
Erik Sahai
Rob Jenkins
Reuben D O'Dea
John R King

Journal of Mathematical Biology

Published 15 June 2021

Crick labs

Erik Sahai

Full details

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling

Authors (11)

Anna Dowbaj
Rob Jenkins
Daniel Williamson
John M Heddleston
Alessandro Ciccarelli
Todd Fallesen
Klaus M Hahn
Reuben D O'Dea
John R King
Marco Montagner
Erik Sahai

Journal of Cell Science

Published 1 July 2021

Crick labs/ facilities

Full details

Selection of metastasis competent subclones in the tumour interior

Authors (27)

Yue Zhao
Xiao Fu
Jose I Lopez
Andrew Rowan
Lewis Au
Annika Fendler
[...]
Paul Bates
Charles Swanton
Samra Turajlic
TRACERx Renal Consortium
Kevin Litchfield

Nature Ecology and Evolution

Published 1 July 2021

Crick labs/ facilities

Full details

Biochemistry: one molecule at a time

Authors (1)

Dominika Gruszka

Essays in Biochemistry

Published 16 April 2021

Crick labs

Erik Sahai

Full details

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

Authors (11)

Manuela Zangrossi
Patrizia Romani
Probir Chakravarty
Colin Ratcliffe
Steven Hooper
Martina Dori
Mattia Forcato
Silvio Bicciato
Sirio Dupont
Erik Sahai
Marco Montagner

Cancers

Published 3 March 2021

Crick labs/ facilities

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A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Authors (7)

Manuela Zangrossi
Probir Chakravarty
Patrizia Romani
Sirio Dupont
Steven Hooper
Erik Sahai
Marco Montagner

Cancers (Basel)

Published 28 February 2021

Crick labs/ facilities

Full details

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Authors (9)

Cell Reports

Published 16 February 2021

Crick labs/ facilities

Full details

A FIJI macro for quantifying pattern in extracellular matrix

Authors (11)

Life Science Alliance

Published 1 March 2021

Crick labs/ facilities

Full details

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

Authors (20)

Oshrat Levi-Galibov
Hagar Lavon
Rina Wassermann-Dozorets
Meirav Pevsner-Fischer
Shimrit Mayer
Esther Wershof
[...]
John A Porco
Erik Sahai
Dror S Shouval
David Kelsen
Ruth Scherz-Shouval

Nature Communications

Published 7 December 2020

Crick labs

Erik Sahai

Full details

CAFs and cancer cells co-migration in 3D spheroid invasion assay

Authors (6)

Sefora Conti
Takuya Kato
Danielle Park
Erik Sahai
Xavier Trepat
Anna Labernadie

Methods in Molecular Biology

Published 1 January 2021

Crick labs

Erik Sahai

Full details

The brain microenvironment induces DNMT1 suppression and indolence of metastatic cancer cells

Authors (10)

Eishu Hirata
Kojiro Ishibashi
Shinji Kohsaka
Keiko Shinjo
Shinya Kojima
Yutaka Kondo
Hiroyuki Mano
Seiji Yano
Etsuko Kiyokawa
Erik Sahai

iScience

Published 25 September 2020

Crick labs/ facilities

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

Authors (10)

Esther Arwert
Emma Milford
Toni Rullan Iriarte
Stefanie Derzsi
Steven Hooper
Takuya Kato
David Mansfield
Alan Melcher
Kevin J Harrington
Erik Sahai

Nature Cell Biology

Published 1 July 2020

Crick labs/ facilities

Full details

SnapShot: Cancer-associated fibroblasts

Authors (3)

Cell

Published 16 April 2020

Crick labs

Erik Sahai

Full details

In vitro Models of Breast Cancer Metastatic Dormancy

Authors (2)

Marco Montagner
Erik Sahai

Front Cell Dev Biol

Published 3 March 2020

Crick labs

Erik Sahai

Full details

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Authors (12)

Marco Montagner
Rahul Bhome
Steven Hooper
Probir Chakravarty
Xiao Qin
Jahangir Sufi
[...]
Colin Ratcliffe
Yutaka Naito
Arianna Pocaterra
Christopher J Tape
Erik Sahai

Nature Cell Biology

Published 1 March 2020

Crick labs/ facilities

Full details

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: Publications

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Publications

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Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling

The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis

Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling

Selection of metastasis competent subclones in the tumour interior

Biochemistry: one molecule at a time

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

A FIJI macro for quantifying pattern in extracellular matrix

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

CAFs and cancer cells co-migration in 3D spheroid invasion assay

The brain microenvironment induces DNMT1 suppression and indolence of metastatic cancer cells

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

SnapShot: Cancer-associated fibroblasts

In vitro Models of Breast Cancer Metastatic Dormancy

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

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