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Breadcrumb Greg Findlay Findlay lab Genome Function Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Areas of interest Publications Publications Displaying 1 - 12 of 12Last updated : 07 June 2023 02:45 Linking genome variants to disease: Scalable approaches to test the functional impact of human mutations Authors (1)Greg Findlay Human Molecular Genetics Published 15 October 2021 Crick labsGreg FindlayFull details Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement Authors (4) Jes AlexanderGreg Findlay Martin Kircher Jay Shendure BMC Biology Published 1 December 2019 Crick labsGreg FindlayFull details Genomic medicine–progress, pitfalls, and promise Authors (3) Jay ShendureGreg Findlay Matthew W Snyder Cell Published 21 March 2019 Crick labsGreg FindlayFull details Accurate classification of BRCA1 variants with saturation genome editing Authors (10)Greg Findlay Riza M Daza Beth Martin Melissa D Zhang Anh P Leith Molly Gasperini Joseph D Janizek Xingfan Huang Lea M Starita Jay Shendure Nature Published 11 October 2018 Crick labsGreg FindlayFull details CRISPR/Cas9-mediated scanning for regulatory elements required for HPRT1 expression via thousands of large, programmed genomic deletions Authors (8) Molly GasperiniGreg Findlay Aaron McKenna Jennifer H Milbank Choli Lee Melissa D Zhang Darren A Cusanovich Jay Shendure American Journal of Human Genetics Published 3 August 2017 Crick labsGreg FindlayFull details Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy Authors (18) François Aguet Srigokul Upadhyayula Raphaël Gaudin Yi-ying Chou Emanuele Cocucci Kangmin He[...] Eric Marino Gaudenz Danuser Sean Megason Eric Betzig Tom Kirchhausen Molecular Biology of the Cell Published 7 November 2016 Crick labsGreg FindlayFull details Whole-organism lineage tracing by combinatorial and cumulative genome editing Authors (6) Aaron McKennaGreg Findlay James A Gagnon Marshall S Horwitz Alexander F Schier Jay Shendure Science Published 29 July 2016 Crick labsGreg FindlayFull details Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation Authors (11) Ramon Y Birnbaum Rupali P Patwardhan Mee J KimGreg Findlay Beth Martin Jingjing Zhao Robert JA Bell Robin P Smith Angel A Ku Jay Shendure Nadav Ahituv PLOS Genetics Published 23 October 2014 Crick labsGreg FindlayFull details Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course Authors (20) Akash Kumar Max DoughertyGreg Findlay Madeleine Geisheker Jason Klein John Lazar[...] Qian Zhou Kelly Smith John I Clark Jay Shendure Marshall S Horwitz PLOS ONE Published 5 September 2014 Crick labsGreg FindlayFull details Saturation editing of genomic regions by multiplex homology-directed repair Authors (5)Greg Findlay Evan A Boyle Ronald J Hause Jason C Klein Jay Shendure Nature Published 4 September 2014 Crick labsGreg FindlayFull details An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry Authors (9) Sonia Sharma Ariel QuintanaGreg Findlay Marcel Mettlen Beate Baust Mohit Jain Roland Nilsson Anjana Rao Patrick G Hogan Nature Published 11 July 2013 Crick labsGreg FindlayFull details Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex Authors (10) Sonia SharmaGreg Findlay Hozefa S Bandukwala Shalini Oberdoerffer Beate Baust Zhigang Li Valentina Schmidt Patrick G Hogan David B Sacks Anjana Rao Proceedings of the National Academy of Sciences of USA Published 12 July 2011 Crick labsGreg FindlayFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Linking genome variants to disease: Scalable approaches to test the functional impact of human mutations Authors (1)Greg Findlay Human Molecular Genetics Published 15 October 2021 Crick labsGreg FindlayFull details
Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement Authors (4) Jes AlexanderGreg Findlay Martin Kircher Jay Shendure BMC Biology Published 1 December 2019 Crick labsGreg FindlayFull details
Genomic medicine–progress, pitfalls, and promise Authors (3) Jay ShendureGreg Findlay Matthew W Snyder Cell Published 21 March 2019 Crick labsGreg FindlayFull details
Accurate classification of BRCA1 variants with saturation genome editing Authors (10)Greg Findlay Riza M Daza Beth Martin Melissa D Zhang Anh P Leith Molly Gasperini Joseph D Janizek Xingfan Huang Lea M Starita Jay Shendure Nature Published 11 October 2018 Crick labsGreg FindlayFull details
CRISPR/Cas9-mediated scanning for regulatory elements required for HPRT1 expression via thousands of large, programmed genomic deletions Authors (8) Molly GasperiniGreg Findlay Aaron McKenna Jennifer H Milbank Choli Lee Melissa D Zhang Darren A Cusanovich Jay Shendure American Journal of Human Genetics Published 3 August 2017 Crick labsGreg FindlayFull details
Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy Authors (18) François Aguet Srigokul Upadhyayula Raphaël Gaudin Yi-ying Chou Emanuele Cocucci Kangmin He[...] Eric Marino Gaudenz Danuser Sean Megason Eric Betzig Tom Kirchhausen Molecular Biology of the Cell Published 7 November 2016 Crick labsGreg FindlayFull details
Whole-organism lineage tracing by combinatorial and cumulative genome editing Authors (6) Aaron McKennaGreg Findlay James A Gagnon Marshall S Horwitz Alexander F Schier Jay Shendure Science Published 29 July 2016 Crick labsGreg FindlayFull details
Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation Authors (11) Ramon Y Birnbaum Rupali P Patwardhan Mee J KimGreg Findlay Beth Martin Jingjing Zhao Robert JA Bell Robin P Smith Angel A Ku Jay Shendure Nadav Ahituv PLOS Genetics Published 23 October 2014 Crick labsGreg FindlayFull details
Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course Authors (20) Akash Kumar Max DoughertyGreg Findlay Madeleine Geisheker Jason Klein John Lazar[...] Qian Zhou Kelly Smith John I Clark Jay Shendure Marshall S Horwitz PLOS ONE Published 5 September 2014 Crick labsGreg FindlayFull details
Saturation editing of genomic regions by multiplex homology-directed repair Authors (5)Greg Findlay Evan A Boyle Ronald J Hause Jason C Klein Jay Shendure Nature Published 4 September 2014 Crick labsGreg FindlayFull details
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry Authors (9) Sonia Sharma Ariel QuintanaGreg Findlay Marcel Mettlen Beate Baust Mohit Jain Roland Nilsson Anjana Rao Patrick G Hogan Nature Published 11 July 2013 Crick labsGreg FindlayFull details
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex Authors (10) Sonia SharmaGreg Findlay Hozefa S Bandukwala Shalini Oberdoerffer Beate Baust Zhigang Li Valentina Schmidt Patrick G Hogan David B Sacks Anjana Rao Proceedings of the National Academy of Sciences of USA Published 12 July 2011 Crick labsGreg FindlayFull details
