Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Vacancies Find links to current vacancies, and information about recruitment to various types of role.
Outwitting Cancer25 Sep -15 Jul Meet the Crick's trailblazing scientists who are helping to turn the tide on one of the world’s biggest killers.
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Paul Nurse Nurse lab Cell Cycle Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Schizosaccharomyces pombe cells expressing cdc2-mNeonGreen (green), and cell walls stained with Calcofluor (magenta). Toggle to view hero caption PublicationsYear published2021 (13)2020 (8)2019 (7)2018 (7)2017 (9)2016 (11)2015 (8)2014 (3)2013 (3)2012 (8)2011 (7)2010 (6) Facet Year publishedResearch topicsBiochemistry & Proteomics (60)Cell Biology (60)Cell Cycle & Chromosomes (60)Chemical Biology & High Throughput (60)Computational & Systems Biology (60)Genetics & Genomics (60)Model Organisms (60)Synthetic Biology (60)Genome Integrity & Repair (8)Structural Biology & Biophysics (7)Immunology (5)Infectious Disease (5)Tumour Biology (5)Human Biology & Physiology (3)Imaging (3)Signalling & Oncogenes (2)Stem Cells (2)Developmental Biology (1)Gene Expression (1)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1) Facet Research topicsPublication typeJournal article (90)Primary research (52)Review (21)Commentary (9)Editorial (4)Letter (3)Method (1) Facet Publication typeJournalJournal of Cell Science (9)Cell (5)Nature (4)Nature Communications (4)Nucleic Acids Research (4)Biochemical Journal (3)Cell Cycle (3)PLOS Genetics (3)Science (3)BMC Biology (2)Current Biology (2)Genes & Development (2)Molecular Biology of the Cell (2)Molecular Cell (2)Open Biology (2)Scientific Reports (2)Annual Review of Cell and Developmental Biology (1)Biologist (1)BMC Genomics (1)Cancer Discovery (1)Cell Reports (1)Cold Spring Harbor Protocols (1)Current Genetics (1)Current Opinion in Cell Biology (1)Database (Oxford) (1)Ecancermedicalscience (1)eLife (1)ESMO Open (1)FEBS Letters (1)Genetics (1)Genome Biology (1)Genome Research (1)Heredity (1)Journal of Biological Education (1)Lancet (1)Lancet Oncology (1)Methods (1)Methods in Molecular Biology (1)Microbial Cell (1)Molecular Medicine (1)Natural Products and Bioprospecting (1)Nature Biotechnology (1)Nature Cell Biology (1)Nature Genetics (1)New Scientist (1)Notes and Records of the Royal Society of London (1)Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1)PLOS Biology (1)PLoS Computational Biology (1)PLOS ONE (1)RSC Advances: an international journal to further the chemical sciences (1)Scientific American (1)The EMBO Journal (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 90Last updated : 28 March 2023 03:05 Fission stories: using PomBase to understand Schizosaccharomyces pombe biology Authors (8) Midori A Harris Kim M RutherfordJacky Hayles Antonia Lock Jürg Bähler Stephen G Oliver Juan Mata Valerie Wood Genetics Published 23 December 2021 Crick labsPaul NurseFull details A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsPeptide ChemistryLight MicroscopyFull details Ana Bolhaqueiro 6 Bolhaqueiro AnaEmail address @email POSTDOCTORAL TRAINING FELLOW On Off Off On Vincent lab Epithelial Cell Interactions Laboratory Search engines may index Identification of novel microtubule inhibitors effective in fission yeast and human cells and their effects on breast cancer cell lines Authors (2) Jun MorishitaPaul Nurse Open Biology Published 1 September 2021 Crick labsPaul NurseFull details The TOR-dependent phosphoproteome and regulation of cellular protein synthesis Authors (3)Tiffany MakAndrew JonesPaul Nurse The EMBO Journal Published 16 August 2021 Crick labs/ facilitiesPaul NurseProteomicsFlow CytometryFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details CDK control pathways integrate cell size and ploidy information to control cell division Authors (4) James Oliver PattersonSaz Basu Paul ReesPaul Nurse eLife Published 11 June 2021 Crick labsPaul NurseFull details An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques Authors (6)Dhira JoshiJennifer MilliganTheresa ZeisnerNicola O'ReillyJohn DiffleyGeorge Papageorgiou RSC Advances: an international journal to further the chemical sciences Published 8 June 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyPeptide ChemistryMRC Biomedical NMR CentreFull details Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I Authors (5) Wei Ma Jingwen Zhou Jian Chen Antony M Carr Yoshinori Watanabe Genes & Development Published 1 May 2021 Crick labsPaul NurseFull details Screening and purification of natural products from actinomycetes that induce a "rounded" morphological phenotype in fission yeast Authors (9) Richard Alexander Lewis Jenileima Devi Katherine Green Juanjuan Li Adam HopkinsJacky HaylesPaul Nurse Jeff Errington Nicholas Edward Ellis Allenby Natural Products and Bioprospecting Published 1 August 2021 Crick labsPaul NurseFull details Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast Authors (4) Elizabeth Scotchman Kazunori Kume Francisco J NavarroPaul Nurse Journal of Cell Science Published 11 February 2021 Crick labsPaul NurseFull details Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control Authors (1)Paul Nurse Molecular Biology of the Cell Published 15 December 2020 Crick labsPaul NurseFull details The Gene Ontology resource: enriching a GOld mine Authors (1) Gene Ontology Consortium Nucleic Acids Research Published 8 January 2021 Crick labsPaul NurseFull details COVID shows UK–EU collaborations are irreplaceable Authors (6) Benjamin Fernando Gordon Brown Emily Thomas Michael HeadPaul Nurse Martin Rees Nature Published 8 October 2020 Crick labsPaul NurseFull details Closed mitosis requires local disassembly of the nuclear envelope Authors (7) Gautam Dey Siân CulleyScott Curran Uwe Schmidt Ricardo Henriques Wanda Kukulski Buzz Baum Nature Published 3 September 2020 Crick labsPaul NurseFull details Science during lockdown - from virtual seminars to sustainable online communities Authors (9) Francesca Bottanelli Bruno Cadot Felix CampeloScott Curran Patricia M Davidson Gautam Dey Ishier Raote Anne Straube Matthew P Swaffer Journal of Cell Science Published 14 August 2020 Crick labsPaul NurseFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Community curation in PomBase: enabling fission yeast experts to provide detailed, standardized, sharable annotation from research publications Authors (5) Antonia Lock Midori A Harris Kim RutherfordJacky Hayles Valerie Wood Database (Oxford) Published 30 April 2020 Crick labsPaul NurseFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Fission stories: using PomBase to understand Schizosaccharomyces pombe biology Authors (8) Midori A Harris Kim M RutherfordJacky Hayles Antonia Lock Jürg Bähler Stephen G Oliver Juan Mata Valerie Wood Genetics Published 23 December 2021 Crick labsPaul NurseFull details
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsPeptide ChemistryLight MicroscopyFull details
Ana Bolhaqueiro 6 Bolhaqueiro AnaEmail address @email POSTDOCTORAL TRAINING FELLOW On Off Off On Vincent lab Epithelial Cell Interactions Laboratory Search engines may index
Identification of novel microtubule inhibitors effective in fission yeast and human cells and their effects on breast cancer cell lines Authors (2) Jun MorishitaPaul Nurse Open Biology Published 1 September 2021 Crick labsPaul NurseFull details
The TOR-dependent phosphoproteome and regulation of cellular protein synthesis Authors (3)Tiffany MakAndrew JonesPaul Nurse The EMBO Journal Published 16 August 2021 Crick labs/ facilitiesPaul NurseProteomicsFlow CytometryFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
CDK control pathways integrate cell size and ploidy information to control cell division Authors (4) James Oliver PattersonSaz Basu Paul ReesPaul Nurse eLife Published 11 June 2021 Crick labsPaul NurseFull details
An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques Authors (6)Dhira JoshiJennifer MilliganTheresa ZeisnerNicola O'ReillyJohn DiffleyGeorge Papageorgiou RSC Advances: an international journal to further the chemical sciences Published 8 June 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyPeptide ChemistryMRC Biomedical NMR CentreFull details
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I Authors (5) Wei Ma Jingwen Zhou Jian Chen Antony M Carr Yoshinori Watanabe Genes & Development Published 1 May 2021 Crick labsPaul NurseFull details
Screening and purification of natural products from actinomycetes that induce a "rounded" morphological phenotype in fission yeast Authors (9) Richard Alexander Lewis Jenileima Devi Katherine Green Juanjuan Li Adam HopkinsJacky HaylesPaul Nurse Jeff Errington Nicholas Edward Ellis Allenby Natural Products and Bioprospecting Published 1 August 2021 Crick labsPaul NurseFull details
Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast Authors (4) Elizabeth Scotchman Kazunori Kume Francisco J NavarroPaul Nurse Journal of Cell Science Published 11 February 2021 Crick labsPaul NurseFull details
Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control Authors (1)Paul Nurse Molecular Biology of the Cell Published 15 December 2020 Crick labsPaul NurseFull details
The Gene Ontology resource: enriching a GOld mine Authors (1) Gene Ontology Consortium Nucleic Acids Research Published 8 January 2021 Crick labsPaul NurseFull details
COVID shows UK–EU collaborations are irreplaceable Authors (6) Benjamin Fernando Gordon Brown Emily Thomas Michael HeadPaul Nurse Martin Rees Nature Published 8 October 2020 Crick labsPaul NurseFull details
Closed mitosis requires local disassembly of the nuclear envelope Authors (7) Gautam Dey Siân CulleyScott Curran Uwe Schmidt Ricardo Henriques Wanda Kukulski Buzz Baum Nature Published 3 September 2020 Crick labsPaul NurseFull details
Science during lockdown - from virtual seminars to sustainable online communities Authors (9) Francesca Bottanelli Bruno Cadot Felix CampeloScott Curran Patricia M Davidson Gautam Dey Ishier Raote Anne Straube Matthew P Swaffer Journal of Cell Science Published 14 August 2020 Crick labsPaul NurseFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Community curation in PomBase: enabling fission yeast experts to provide detailed, standardized, sharable annotation from research publications Authors (5) Antonia Lock Midori A Harris Kim RutherfordJacky Hayles Valerie Wood Database (Oxford) Published 30 April 2020 Crick labsPaul NurseFull details