Publications

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

Authors (12)

Matthew C Frise
David A Holdsworth
Andrew W Johnson
Yu Jin Chung
M Kate Curtis
Pete J Cox
[...]
Damian J Tyler
David J Roberts
Peter Ratcliffe
Keith L Dorrington
Peter A Robbins

Scientific Reports

Published 19 January 2022

Crick labs

Peter Ratcliffe

Full details

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine

Authors (1)

Peter Ratcliffe

Clinical medicine (London, England)

Published 1 January 2022

Crick labs

Peter Ratcliffe

Full details

Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischemia-reperfusion injury

Authors (11)

Michael Harris
Junhui Sun
Karen Keeran
Angel Aponte
Komudi Singh
Danielle Springer
Marjan Gucek
Mehdi Pirooznia
Matthew Cockman
Elizabeth Murphy
Leslie M Kennedy

Cardiovascular Research

Published 20 October 2021

Crick labs

Peter Ratcliffe

Full details

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Authors (10)

Luise Eckardt
Maria Prange-Barczynska
Emma J Hodson
James W Fielding
Xiaotong Cheng
Joanna DCC Lima
Samvid Kurlekar
Gillian Douglas
Peter Ratcliffe
Tammie Bishop

Endocrine-Related Cancer

Published 18 October 2021

Crick labs

Peter Ratcliffe

Full details

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Authors (15)

Brian M Ortmann
Natalie Burrows
Ian T Lobb
Esther Arnaiz
Niek Wit
Peter SJ Bailey
[...]
Rachel Seear
David R Mole
Peter Ratcliffe
Patrick H Maxwell
James A Nathan

Nature Genetics

Published 1 July 2021

Crick labs

Peter Ratcliffe

Full details

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Authors (23)

Peter AC Wing
Thomas P Keeley
Xiaodong Zhuang
Jeffrey Y Lee
Maria Prange-Barczynska
Senko Tsukuda
[...]
Peter Ratcliffe
Ilan Davis
Emma J Hodson
Tammie Bishop
Jane A McKeating

Cell Reports

Published 20 April 2021

Crick labs

Peter Ratcliffe

Full details

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia

Authors (11)

Aline Jatho
Anke Zieseniss
Katja Brechtel-Curth
Atsushi Yamamoto
Mathew L Coleman
Ana M Vergel Leon
Daniel Biggs
Ben Davies
Chris W Pugh
Peter Ratcliffe
Dörthe M Katschinski

Circulation Research

Published 16 April 2021

Crick labs

Peter Ratcliffe

Full details

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Authors (14)

Victoria Lauer
Steffen Grampp
James Platt
Veronique Lafleur
Olivia Lombardi
Hani Choudhry
[...]
Atsushi Yamamoto
Mathew L Coleman
Peter Ratcliffe
David R Mole
Johannes Schödel

Journal of Biological Chemistry

Published 27 March 2020

Crick labs

Peter Ratcliffe

Full details

Endothelial oxygen sensing in alveolar maintenance

Authors (2)

Emma Hodson
Peter Ratcliffe

American Journal of Respiratory and Critical Care Medicine

Published 1 October 2020

Crick labs

Peter Ratcliffe

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophia Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Authors (17)

Xiaotong Cheng
Maria Prange-Barczynska
James W Fielding
Minghao Zhang
Alana L Burrell
Joanna DCC Lima
[...]
Richard K Bruick
Lucy Collinson
Fraydoon Rastinejad
Tammie Bishop
Peter Ratcliffe

Journal of Clinical Investigation

Published 1 May 2020

Crick labs/ facilities

Full details

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Authors (2)

Tammie Bishop
Peter Ratcliffe

Science Signaling

Published 21 January 2020

Crick labs

Peter Ratcliffe

Full details

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Authors (10)

Virginia Schmid
Veronique N Lafleur
Olivia Lombardi
Ran Li
Rafik Salama
Leandro Colli
Hani Choudhry
Stephen Chanock
Peter Ratcliffe
David R Mole

Scientific Reports

Published 10 December 2019

Crick labs

Peter Ratcliffe

Full details

Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

Authors (13)

James P Holt-Martyn
Rasheduzzaman Chowdhury
Anthony Tumber
Tzu-Lan Yeh
Martine I Abboud
Kerstin Lippl
[...]
Jr Figg
Michael A McDonough
Christopher W Pugh
Peter Ratcliffe
Christopher J Schofield

ChemMedChem

Published 5 February 2020

Crick labs

Peter Ratcliffe

Full details

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Authors (14)

Victoria Lauer
Steffen Grampp
James Platt
Veronique Lafleur
Olivia Lombardi
Hani Choudhry
[...]
Atsushi Yamamoto
Mathew L Coleman
Peter Ratcliffe
David R Mole
Johannes Schödel

Journal of Biological Chemistry

Published 27 March 2020

Crick labs

Peter Ratcliffe

Full details

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Authors (11)

Matthew Cockman
Kerstin Lippl
Ya-Min Tian
Hamish Pegg
William D Figg
Martine I Abboud
Raphael Heilig
Roman Fischer
Johanna Myllyharju
Christopher J Schofield
Peter Ratcliffe

eLife

Published 10 September 2019

Crick labs/ facilities

Full details

Mechanisms of hypoxia signalling: new implications for nephrology

Authors (2)

Johannes Schödel
Peter Ratcliffe

Nature Reviews Nephrology

Published 1 October 2019

Crick labs

Peter Ratcliffe

Full details

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Authors (10)

Norma Masson
Thomas P Keeley
Beatrice Giuntoli
Mark D White
Mikel Lavilla Puerta
Pierdomenico Perata
Richard J Hopkinson
Emily Flashman
Francesco Licausi
Peter Ratcliffe

Science

Published 5 July 2019

Crick labs

Peter Ratcliffe

Full details

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Authors (25)

Atsushi Yamamoto
Joanna Hester
Philip S Macklin
Kento Kawai
Masateru Uchiyama
Daniel Biggs
[...]
Cheryl L Scudamore
Elizabeth Soilleux
Fadi Issa
Peter Ratcliffe
Chris W Pugh

Journal of Clinical Investigation

Published 3 September 2019

Crick labs

Peter Ratcliffe

Full details

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Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine

Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischemia-reperfusion injury

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Endothelial oxygen sensing in alveolar maintenance

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

Mechanisms of hypoxia signalling: new implications for nephrology

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

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