Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Vacancies Find links to current vacancies, and information about recruitment to various types of role.
Outwitting Cancer25 Sep -15 Jul Meet the Crick's trailblazing scientists who are helping to turn the tide on one of the world’s biggest killers.
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Proteomics Proteomics : Publications Lab contentLab contentIn this section Overview Publications Members The Mass Spectrometry Proteomics STP. Toggle to view hero caption Publications Displaying 1 - 10 of 188Last updated : 07 June 2023 02:54 Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 29 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsPeptide ChemistryLight MicroscopyFull details Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B Authors (5)Jonathan BaileyHolly DouglasLaura MasinoLuiz Pedro Carvalho Argyrides Argyrou Biochemistry Published 30 November 2021 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyProteomicsFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling Authors (5)Paulo Da Costa Gameiro Guerreiro Vesela EnchevaMariana Silva Dos SantosJames MacraeJernej Ule Journal of Biological Chemistry Published 1 November 2021 Crick labs/ facilitiesJernej UleProteomicsMetabolomicsFull details Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions Authors (8)Saira Hussain Rodney S Daniels Stephen A Wharton Steven Howell Chandrika HalaiSimone Kunzelmann Lynne WhittakerJohn Mccauley Journal of General Virology Published 1 October 2021 Crick labs/ facilitiesJohn McCauleyWorldwide Influenza CentreStructural BiologyProteomicsFull details Development of a fluorogenic ADAMTS-7 substrate Authors (11) Salvatore Santamaria Frederic Buemi Elisa Nuti Doretta Cuffaro Elena De Vita Tiziano Tuccinardi Armando Rossello Steven HowellShahid MehmoodBram Snijders Rens de Groot Journal of Enzyme Inhibition and Medicinal Chemistry Published 30 September 2021 Crick labs/ facilitiesProteomicsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 29 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsPeptide ChemistryLight MicroscopyFull details
Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B Authors (5)Jonathan BaileyHolly DouglasLaura MasinoLuiz Pedro Carvalho Argyrides Argyrou Biochemistry Published 30 November 2021 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyProteomicsFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details
Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling Authors (5)Paulo Da Costa Gameiro Guerreiro Vesela EnchevaMariana Silva Dos SantosJames MacraeJernej Ule Journal of Biological Chemistry Published 1 November 2021 Crick labs/ facilitiesJernej UleProteomicsMetabolomicsFull details
Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions Authors (8)Saira Hussain Rodney S Daniels Stephen A Wharton Steven Howell Chandrika HalaiSimone Kunzelmann Lynne WhittakerJohn Mccauley Journal of General Virology Published 1 October 2021 Crick labs/ facilitiesJohn McCauleyWorldwide Influenza CentreStructural BiologyProteomicsFull details
Development of a fluorogenic ADAMTS-7 substrate Authors (11) Salvatore Santamaria Frederic Buemi Elisa Nuti Doretta Cuffaro Elena De Vita Tiziano Tuccinardi Armando Rossello Steven HowellShahid MehmoodBram Snijders Rens de Groot Journal of Enzyme Inhibition and Medicinal Chemistry Published 30 September 2021 Crick labs/ facilitiesProteomicsFull details