Peptide Chemistry : Areas of Interest

We make peptides for Crick researchers for use in experiments to study how biomolecules such as proteins interact with each other.

We synthesise small molecules, such as enzyme inhibitors, modified nucleotides and cross-linking agents by solution phase chemistry techniques.

Many protein-protein interactions can be studied using a synthetic peptide as one of the partners. We make peptide arrays on cellulose membranes, which can be probed by an interacting protein to allow the study of molecular recognition events.

Medicinal chemists at the Crick can offer guidance on best practice in chemical probe synthesis, selection, evaluation and use for testing a biological hypothesis.