A comprehensive survey of the mutagenic impact of common cancer cytotoxics

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Genomic mutations caused by cytotoxic agents used in cancer chemotherapy may cause secondary malignancies as well as contribute to the evolution of treatment-resistant tumour cells. The stable diploid genome of the chicken DT40 lymphoblast cell line, an established DNA repair model system, is well suited to accurately assay genomic mutations.

Journal details

Journal Genome Biology
Volume 17
Issue number 1
Pages 99-99
Available online
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