A roadmap for the Human Developmental Cell Atlas
Authors listMuzlifah Haniffa Deanne Taylor Sten Linnarsson Bruce J Aronow Gary D Bader Roger A Barker Pablo G Camara J Gray Camp Alain Chédotal Andrew Copp Heather C Etchevers Paolo Giacobini Berthold Göttgens Guoji Guo Ania Hupalowska Kylie R James Emily Kirby Arnold Kriegstein Joakim Lundeberg John C Marioni Kerstin B Meyer Kathy Niakan Mats Nilsson Bayanne Olabi Dana Pe'er Aviv Regev Jennifer Rood Orit Rozenblatt-Rosen Rahul Satija Sarah A Teichmann Barbara Treutlein Roser Vento-Tormo Simone Webb Human Cell Atlas Developmental Biological Network
Toggle all authors (34)
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.