Cell division: Switching on ECT2 in a non-canonical fashion
Authors listMark Petronczki Antonio Tedeschi
Determining the site of cell cleavage is crucial for cytokinesis and involves precise activation of the RhoGEF ECT2. A new study demonstrates how a non-canonical interaction of ECT2 with centralspindlin underlies cytokinesis in animal cells, solving a mechanistic conundrum.
Journal Current Biology
Issue number 16