Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomographyMore about Open Access at the Crick
Authors listHanif Esmail Rachel Lai Maia Lesosky Katalin Wilkinson Christine Graham Anna K Coussens Tolu Oni James M Warwick Qonita Said-Hartley Coenraad F Koegelenberg Gerhard Walzl JoAnne L Flynn Douglas B Young Clifton E Barry III Anne O'Garra Robert Wilkinson
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
Journal Nature Medicine
Issue number 10