Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine


The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

Journal details

Journal Genome Biology
Volume 15
Issue number 8
Pages 453
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Type of publication