DNA replication stress mediates APOBEC3 family mutagenesis in breast cancerMore about Open Access at the Crick
Authors listNnennaya Kanu Maria Antonietta Cerone Gerald Goh Panos Zalmas Jirina Bartkova Michelle Dietzen Nicholas McGranahan Rebecca Rogers Emily K Law Irina Gromova Maik Kschischo Michael I Walton Olivia W Rossanese Jiri Bartek Reuben S Harris Subramanian Venkatesan Charles Swanton
The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to identify a molecular basis for APOBEC3 expression and activation.
Journal Genome Biology
Issue number 1