Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases


Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlying mechanisms are poorly defined and no current antituberculous therapy reduces host tissue damage.

Journal details

Volume 185
Issue number 9
Pages 989-997
Publication date


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