Dynamics of the actin cytoskeleton mediates receptor cross talk: an emerging concept in tuning receptor signaling
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Pieta K Mattila Facundo D Batista Bebhinn TreanorAbstract
Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.
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Journal Journal of Cell Biology
Volume 212
Issue number 3
Pages 267-280
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Publisher website (DOI) 10.1083/jcb.201504137
Europe PubMed Central 26833785
Pubmed 26833785
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