Emerging details shed light on mammalian autophagy: Molecules and membranes


Autophagy, which literally means 'self eating', is a highly conserved intracellular degradative process mediated by lysosomal enzymes. Autophagy was identified using electron microscopy in the 1950s by cell biologists studying the lysosome and it was recognized as a lysosomal degradative pathway (for a review of the original publications, see Tooze et al.) Recently, a number of key findings have elucidated the pivotal role played by autophagy in tissue homoeostasis and human disease, such as cancer, neurodegeneration, infection, immunity and aging. Autophagy is also tightly linked to neonatal survival and cellular metabolism. © Biochemical Society.

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Journal Biochemist
Volume 34
Issue number 2
Pages 4-7
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