HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcriptionMore about Open Access at the Crick
Authors listOphélie Cosnefroy Philip J Murray Kate Bishop
Correct disassembly of the HIV-1 capsid shell, called uncoating, is increasingly recognised as central for multiple steps during retroviral replication. However, the timing, localisation and mechanism of uncoating are poorly understood and progress in this area is hampered by difficulties in measuring the process. Previous work suggested that uncoating occurs soon after entry of the viral core into the cell, but recent studies report later uncoating, at or in the nucleus. Furthermore, inhibiting reverse transcription delays uncoating, linking these processes.
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