HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

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Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.

Journal details

Volume 38
Issue number 2
Pages 185-198
Available online
Publication date

Crick authors

Crick First author
Crick Corresponding author