HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis

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Chloé Loiseau Daniela Brites Miriam Reinhard Kathrin Zürcher Sonia Borrell Marie Ballif Lukas Fenner Helen Cox Liliana K Rutaihwa Robert Wilkinson Marcel Yotebieng E Jane Carter Alash'le Abimiku Olivier Marcy Eduardo Gotuzzo Anchalee Avihingsanon Nicola Zetola Basra Doulla Erik C Böttger Matthias Egger Sebastien Gagneux
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Abstract

We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.

Journal details

Journal Antimicrobial Agents and Chemotherapy
Volume 64
Issue number 10
Pages e00782-20
Available online
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Publisher website (DOI) 10.1128/AAC.00782-20
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Europe PubMed Central 32718966
Pubmed 32718966

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