Improving the microbiological diagnosis of tuberculous meningitis: A prospective, international, multicentre comparison of conventional and modified Ziehl-Neelsen stain, GeneXpert, and culture of cerebrospinal fluid

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A Dorothee Heemskerk Joseph Donovan Do Dang Anh Thu Suzaan Marais Lidya Chaidir Vu Thi Mong Dung Chad M Centner Vu Thi Ngoc Ha Jessi Annisa Sofiati Dian Louise Bovijn Nguyen Thi Hoang Mai Nguyen Hoan Phu Nguyen Van Vinh Chau Ahmad Rizal Ganiem Cao Thao Van Ronald B Geskus Nguyen Thuy Thuong Thuong Rovina Ruslami Graeme Meintjes Reinout van Crevel Robert Wilkinson Guy E Thwaites
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Abstract

Tuberculous meningitis (TBM) is the severest form of tuberculosis, but current diagnostic tests are insensitive. Recent reports suggest simple modifications to conventional cerebrospinal fluid (CSF) Ziehl-Neelsen (ZN) staining may greatly improve sensitivity. We sought to define the performance of modified and conventional ZN stain for TBM diagnosis.

Journal details

Journal Journal of Infection
Volume 77
Issue number 6
Pages 509-515
Available online
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Publisher website (DOI) 10.1016/j.jinf.2018.09.003
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Europe PubMed Central 30217659
Pubmed 30217659

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