Inhibiting the inhibitor: the role of RNF12 in TGF-β superfamily signaling


In this issue of Molecular Cell, Zhang et al. (2012) identify the E3 ubiquitin ligase RNF12 as a new component of the TGF-β superfamily signaling pathways, which functions by targeting the negative regulator Smad7 for proteasomal degradation and thus potentiates pathway activity.

Journal details

Journal Molecular Cell
Volume 46
Issue number 5
Pages 558-559
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