mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

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Abstract

SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear.

Journal details

Volume 20
Issue number 4
Pages 393-405
Available online
Publication date