Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
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Nikaïa Smith Nicolas Pietrancosta Sophia Davidson Jacques Dutrieux Lise Chauveau Pasquale Cutolo Michel Dy Daniel Scott-Algara Bénédicte Manoury Onofrio Zirafi Isabelle McCort-Tranchepain Thierry Durroux Françoise Bachelerie Olivier Schwartz Jan Münch Andreas Wack Sébastien Nisole Jean-Philippe HerbeuvalAbstract
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
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Journal Nature Communications
Volume 8
Pages 14253
Available online
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Publisher website (DOI) 10.1038/ncomms14253
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Europe PubMed Central 28181493
Pubmed 28181493
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