Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagementMore about Open Access at the Crick
Authors listNikaïa Smith Nicolas Pietrancosta Sophia Davidson Jacques Dutrieux Lise Chauveau Pasquale Cutolo Michel Dy Daniel Scott-Algara Bénédicte Manoury Onofrio Zirafi Isabelle McCort-Tranchepain Thierry Durroux Françoise Bachelerie Olivier Schwartz Jan Münch Andreas Wack Sébastien Nisole Jean-Philippe Herbeuval
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
Journal Nature Communications