The interplay of leukemia cells and the bone marrow microenvironment


The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models has advanced our comprehension of leukemia-microenvironment crosstalk and has potential implications for development of novel treatment options.

Journal details

Journal Blood
Volume 131
Issue number 14
Pages 1507-1511
Publication date


Type of publication

Crick labs/facilities