The interplay of leukemia cells and the bone marrow microenvironment
Authors listDelfim Duarte Edwin D Hawkins Cristina Lo Celso
The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models has advanced our comprehension of leukemia-microenvironment crosstalk and has potential implications for development of novel treatment options.
Issue number 14
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Publisher website (DOI) 10.1182/blood-2017-12-784132
Europe PubMed Central 29487069
Type of publication