The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosisMore about Open Access at the Crick
Authors listSimon Blankley Christine Graham Jacob Turner Matthew PR Berry Chloe I Bloom Zhaohui Xu Virginia Pascual Jacques Banchereau Damien Chaussabel Ronan Breen George Santis Derek M Blankenship Marc Lipman Anne O'Garra
Mycobacterium tuberculosis infection is a leading cause of infectious death worldwide. Gene-expression microarray studies profiling the blood transcriptional response of tuberculosis (TB) patients have been undertaken in order to better understand the host immune response as well as to identify potential biomarkers of disease. To date most of these studies have focused on pulmonary TB patients with gene-expression profiles of extra-pulmonary TB patients yet to be compared to those of patients with pulmonary TB or sarcoidosis.
Journal PLOS ONE
Issue number 10