Toward understanding and exploiting tumor heterogeneity
Authors listAsh A Alizadeh Victoria Aranda Alberto Bardelli Cedric Blanpain Christoph Bock Christine Borowski Carlos Caldas Andrea Califano Michael Doherty Markus Elsner Manel Esteller Rebecca Fitzgerald Jan O Korbel Peter Lichter Christopher E Mason Nicholas Navin Dana Pe'er Kornelia Polyak Charles WM Roberts Lillian Siu Alexandra Snyder Hannah Stower Charles Swanton Roel GW Verhaak Jean C Zenklusen Johannes Zuber Jessica Zucman-Rossi
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The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here.
Journal Nature Medicine
Issue number 8