Visualizing the dynamics of tuberculosis pathology using molecular imagingMore about Open Access at the Crick
Authors listAlvaro A Ordonez Elizabeth W Tucker Carolyn J Anderson Claire L Carter Shashank Ganatra Deepak Kaushal Igor Kramnik Philana L Lin Cressida A Madigan Susana Mendez Jianghong Rao Rada M Savic David M Tobin Gerhard Walzl Robert Wilkinson Karen A Lacourciere Laura E Via Sanjay K Jain
Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
Issue number 5