Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?
Authors listJuliane Liepe Huib Ovaa Michele Mishto
The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds.
Journal Current Opinion in Immunology
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Publisher website (DOI) 10.1016/j.coi.2018.04.016
Europe PubMed Central 29723668
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