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Latest Publications

Displaying 1 - 20 of 88
Last updated : 01 December 2022 02:09

Laboratory Research Scientist - Human Embryo and Stem Cell Unit

Submitted by codeenigma-mas… on 20 September 2021

Reports to:

Principle Laboratory Research Scientist

Contact term:

This is a full-time, permanent position on Crick terms and conditions of employment.


The area of pluripotent stem cell research is a dynamic field with a broad scope of applications due to the ability of the cells to differentiate down lineages representative of all three germ layers. Apart from the potential clinical application of human pluripotent stem cells in the field of cell therapies, the use of these cells is well established in areas of assay development, modelling of developmental pathways and disease modelling. The utilisation of these applications coupled with the use of gene editing tools such as CRISPR makes this type of biological system ideal to study the effects of gene knockout or gene modification. The Human Embryo and Stem Cell Unit (HESCU) is a core facility and supports and develops workflows with Crick scientists that involve the use of human pluripotent stem cells. HESCU has a multidisciplinary user base that is dynamic, evolving and expanding and with this comes the opportunity to be involved in cutting edge research.

Project summary

HESCU provides and maintains a well-equipped laboratory space and as a communal lab space, facilitates interaction between the groups working with human pluripotent stem cells fostering collaboration, exchange of ideas and the sharing of protocols between the scientific groups who use the facility. We currently work with users to provide support and promote best practice, in the areas of growing pluripotent stem cells, differentiation, characterisation, banking and method development. In addition, we are involved in the reprogramming of somatic cells to produce pluripotent stem cell lines. We are looking to extend our portfolio to include gene editing technologies to add value to the core service.

We are looking for a motivated, collaborative, scientist to work with HESCU staff and the user base on established protocols and to help maintain and aid in the development of the portfolio of services offered by this core facility.

Key responsibilities

Provision and support for the day to day running of the facility, ensuring effective service delivery. These responsibilities include but are not limited to:


  • Day to day management of stock
  • Cleaning laboratory spaces and equipment
  • Helping with operational activities and planned preventative maintenance

Provision of media and reagents

  • Inventory and stock control
  • Aliquoting reagents
  • Reagent preparation

Quality Control assisting with adopted methods

  • Immunofluorescence,
  •  RT-PCR, Mycoplasma,
  •  DNA and RNA extraction

Expansion of cell lines

  • Banking cell lines
  • Distribution of cell lines to users
  • Cryopreservation of cell lines
  • Thawing cell lines
  • Stability testing
  • Production of feeder cells

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:


Qualifications, experience and competencies:

  • Degree in a biological subject
  • Experience in cell culture  
  • Excellent communication and presentation skills.
  • Excellent organisational skills and record keeping with attention to detail
  • A good working knowledge of Microsoft Office and internet skills
  • Ability to prioritise workflows and deliver to deadlines
  • Highly self-motivated with a pro-active approach.
  • Proven ability to work both collaboratively and independently.
  • Accurate record keeping


Qualifications, experience and competencies:

  • Experience in human pluripotent stem cell culture
  • Experience in a range of molecular biology techniques including RT-PCR and Real Time qRT-PCR.
  • Experience in Flow Cytometry and Immunofluorescence
  • Excellent inter-personal skills and a willingness to learn new skills
  • Ability to work with diverse databases 36 1 Lyn Healy Stp |Human Embryo And Stem Cell Unit Team (Lyn Healy) Human Embryonic Stem Cell R433 Search engines may index Yes Science 3 <p>Competitive with benefits, subject to skills and experience</p>

ITO Support Engineer

Submitted by codeenigma-mas… on 17 September 2021

Reports to

ITO Helpdesk Manager

This is a permanent position on Crick terms and conditions of employment.


This role will report to the ITO Helpdesk Manager and will be based at the Francis Crick Institute to provide 1/2nd line support. Key responsibilities These include but are not limited to:

  • Working on a shift pattern of 8am – 6pm Mon – Fri in the ITO Helpdesk team, providing a single point of contact service for all Francis Crick employees.
  • Providing 1st and 2nd line ITO support, with primary focus on resolving issues remotely using existing technologies and when necessary by desk visit.
  • Ensuring all technical issues and queries received via phone, email, self-service portal or walk-up are logged, tracked and actioned according to agreed processes and best practice.
  • Providing a service that is responsive to customer needs by solving as many problems as quickly and directly as possible; if necessary, liaising with other ITO staff to complete the resolution of the problems.
  • Participate as required, and as directed by the relevant ITO team members, in the following administrative processes: purchases and asset management (raising orders, monitoring deliveries, returns, etc), recording software licences and managing support contracts for computer hardware and related equipment, general administration and office management.
  • Onboard users as required, including the provisioning of end user devices and the setup of user IT credentials and access to relevant systems.

Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Person Specification

  • Previous experience in an IT helpdesk environment.
  • A proven track record of delivering high quality customer service both in person and on the telephone.
  • A demonstrable ability to prioritise effectively in response to competing demands from customers.
  • A demonstrable ability to “put yourself” in the place of customers and ensure that the service provided is meeting their needs.
  • A “can do” approach to responding to customer queries.
  • Entry level Networking qualification or striving towards.
  • Working knowledge of ITIL best practice for IT support.
  • Good standard of general education, including grade C or above (or equivalent) in GCSE English and Maths.
  • Excellent written and verbal communication skills and attention to detail.
  • Strong organisational skills and a demonstrable ability to manage own time effectively.
  • Strong interpersonal skills and a demonstrable ability to build effective relationships at all levels.
  • Quick learner with proven ability to adapt to changing circumstances.
  • Previous experience of working in science or medical research environments would be an advantage.

Technical Skills

  • Previous experience of using call-logging or job-tracking systems for IT service requests and Incident Management.
  • Previous experience of using ServiceNow an advantage.
  • Demonstrable experience of supporting Apple computers running Mac OS X.
  • Previous experience of troubleshooting both Mac and Windows applications, particularly Microsoft Office 365, Adobe Creative Suite, Virtual Applications, Database connections, Data recovery and OS Patching.
  • Previous experience with using remote software deployment tools, Casper essential.
  • Previous experience of maintaining and troubleshooting IT desktop hardware and software in a networked environment.
  • Previous experience of MS Exchange, Active Directory administration and SharePoint and first line troubleshooting.
  • Experience with MDM and VPN solutions and supporting mobile devices and Tablets, including iOS and Android.
  • Previous experience of supporting and / or setting-up users on telephony using Cisco Call Manager, WebEx and Jabber.
  • Previous experience supporting meeting rooms configuring and troubleshooting video projectors and video conference systems an advantage.
  • Previous experience with Network Patching, including basic knowledge of switch commands and VLANs.
  • Experience building and supporting a mixed Linux environment, predominantly CentOS and Ubuntu.
  • Previous experience supporting hardware on MFD Printers.
  • Experience with deployments, hardware refreshes and desk moves.
  • Knowledge of Linux scripting an advantage.
  • Experience of supporting Scientific Equipment would be an advantage. 36 1 Jude D'Souza Ito Helpdesk Team (Jude D'Souza) R425 Search engines may index Yes Operations 6 <p><span>Competitive with benefits, subject to skills and experience</span></p>