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Breadcrumb Research Research case studies In this sectionSecondary NavigationIn this section A-Z of research labs Platforms & facilities A-Z researchers Applying our research Research partnerships Topics Research reports Publications Covid-19 response Research reportsAt the Crick we work across disciplines to explore biology at all levels, from molecules through cells to entire organisms. Explore a selection of recent case studies that spotlight particular areas of research at the Crick. Publication highlights Every quarter, our faculty select their top publications from the Crick. See the range of research that comes out of the Crick, on neuroscience, immunology, cancer and more. Case studies Telomere end protection: an unexpected twist in the tail Simon Boulton (with Kathy Niakan and James Briscoe) Structural basis for retroviral DNA integration Peter Cherepanov (with Alessandro Costa) In vitro reconstitution of the entire chromatin replication pathway John Diffley (with Alessanro Costa) Neurogenesis in the adult mouse brain François Guillemot Combating intestinal failure with engineered transplantable mucosal grafts Vivian Li (with Paola Bonfanti) Pre-implantation development of human embryos Kathy Niakan Cyclin-dependent kinases and the ordering of the cell cycle Paul Nurse Intron retention serves as a blueprint for RNA binding protein mislocalisation in amyotrophic lateral sclerosis Rickie Patani (with Jernej Ule and Nick Luscombe) Metabolic reprogramming through lysine harvesting strengthens microbial stress defences Markus Ralser A new checkpoint in tumour immunity Caetano Reis e Sousa Getting a handle on ubiquitin E3 ligases Katrin Rittinger (with Crick-GSK LinkLabs) Studying the cell surface glyco-code Ben Schumann (with Vivian Li) Prehistoric dog DNA sheds light on 11,000 years of canine evolution Pontus Skoglund A fundamental role for the aryl hydrocarbon receptor in maintaining intestinal health Brigitta Stockinger and Vassilis Pachnis Taking lessons from cancer evolution to the clinic Charles Swanton (with Peter Van Loo) Tracking the evolution of clear cell renal cell carcinoma through multi-regional sequencing Samra Turajlic and Charles Swanton (with Peter Van Loo) Topological entrapment of DNA by cohesin Frank Uhlmann with Alessandro Costa The evolutionary history of cancer Peter Van Loo A glypican shield permits long-range signalling by Wnt Jean-Paul Vincent A synthetic mophogen reveals principles of tissue patterning Jean-Paul Vincent and Guillaume Salbreux Cancer nutrition Karen Vousden A new vaccine against tuberculosis Robert Wilkinson Highlights of the Crick's response to the COVID-19 pandemic The Crick COVID-19 Consortium Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Publication highlights Every quarter, our faculty select their top publications from the Crick. See the range of research that comes out of the Crick, on neuroscience, immunology, cancer and more.
Telomere end protection: an unexpected twist in the tail Simon Boulton (with Kathy Niakan and James Briscoe)
In vitro reconstitution of the entire chromatin replication pathway John Diffley (with Alessanro Costa)
Combating intestinal failure with engineered transplantable mucosal grafts Vivian Li (with Paola Bonfanti)
Intron retention serves as a blueprint for RNA binding protein mislocalisation in amyotrophic lateral sclerosis Rickie Patani (with Jernej Ule and Nick Luscombe)
Metabolic reprogramming through lysine harvesting strengthens microbial stress defences Markus Ralser
A fundamental role for the aryl hydrocarbon receptor in maintaining intestinal health Brigitta Stockinger and Vassilis Pachnis
Tracking the evolution of clear cell renal cell carcinoma through multi-regional sequencing Samra Turajlic and Charles Swanton (with Peter Van Loo)
A synthetic mophogen reveals principles of tissue patterning Jean-Paul Vincent and Guillaume Salbreux